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  • 1980-1984  (5)
  • 1970-1974  (4)
  • Chemistry  (6)
  • Intervertebral disc  (1)
  • cellularity  (1)
  • hyperprolactinemic drugs  (1)
Source
Material
Years
Year
Keywords
  • 1
    Electronic Resource
    Electronic Resource
    Effects of drugs associated with hyperprolactinemia on plasma steroids and on steroid receptors and metabolism in human breast cancer (1983)
    Springer
    Breast cancer research and treatment 3 (1983), S. 331-338 
    Details
    ISSN: 1573-7217
    Keywords: breast cancer ; estrogen receptor ; hyperprolactinemic drugs ; prolactin ; steroid biosynthesis ; steroid hormones
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Certain commonly taken pharmaceutical preparations induce increased levels of plasma prolactin. The effects of these drugs on (a) tumor steroid receptors and metabolism, and (b) plasma hormones and hormone binding proteins have been studied in postmenopausal women with breast cancer. Two groups have been compared, 18 patients on drug treatment for at least 2 months and 15 subjects with no history of drug ingestion. Patients taking medication had significantly higher levels of plasma prolactin compared with control women. No significant difference was observed between the groups with regard to the plasma concentrations of dehydroepiandrosterone (DHA) and its sulphate (DHS), testosterone, estrone, estradiol-17β, sex hormone binding globulin (SHBG), and albumin. Similarly, no difference was observed between these two groups with regard to estrogen receptor (ER), progestogen receptor (PR), or androgen receptor (AR) levels in the tumors nor their ability to metabolize (7−3H) testosterone. It is considered that the ingestion of these drugs does not affect tumor mechanisms involving steroids.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01807585
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Cellularity and the quantitation of estrogen receptors (1982)
    Springer
    Breast cancer research and treatment 2 (1982), S. 239-242 
    Details
    ISSN: 1573-7217
    Keywords: cellularity ; DNA ; estrogen receptor ; protein ; wet weight
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Fifty estrogen receptor (ER)-positive breast cancers have been studied to determine the best way of correcting for differences in cellularity when expressing ER concentration. ER concentration expressed on wet weight and tumour cytosol protein bases showed a positive correlation with tumour cellularity. In contrast, ER concentrations expressed on a DNA basis were not significantly related to cellularity. Although such a mode of correcting for differences in cellularity was imperfect, it did yield a receptor concentration which was less dependent upon tissue cellularity and which may reflect more accurately the inherent receptor status of the tumour cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01806936
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Studies on immobilized papain (1973)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 15 (1973), S. 455-466 
    Details
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Papain was covalently coupled to ZrO2-coated porous glass by several different methods. These derivatives were characterized and their operational half-lives determined using casein substrate. Papain covalently coupled to the porous glass, previously converted to a carboxylic acid derivative, through amide linkage gave a 35 day operational half-life.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260150303
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Invertase covalently coupled to porous glass: Preparation and characterization (1972)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 14 (1972), S. 637-645 
    Details
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The enzyme invertase has been covalently coupled to porous glass particles. The product is extremely stable over a long period of time. Kinetic values for the immobilized enzyme are similar to the native enzyme. Excellent enzymatic activity for the immobilized enzyme was exhibited over a broad pH range. The immobilized enzyme when continuously operated for one month was found to have an operational half-life of over 40 days.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260140409
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  • 5
    Electronic Resource
    Electronic Resource
    Interaction of human α-thrombin with artificial surfaces and reactivity of adsorbed α-thrombin (1980)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 14 (1980), S. 467-476 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Thrombin adsorbed onto Cuprophane or poly(vinyl chloride) (PVC) was shown to be inactive with respect to amidase activity. Desorbed thrombin from these two artificial surfaces showed only low amidase activity. However, in the presence of albumin, the surface-bound thrombin appeared to exhibit increased amidase activity. This apparent activity may be due to the action of thrombin displaced from the surfaces by albumin. Thrombin bound to Cuprophane or PVC was shown to be capable of reacting with antithrombin III (AT III) only in the presence of heparin. On the other hand, AT III bound to Cuprophane or PVC was unable to react with thrombin in either the absence or presence of heparin. Fibrin formation on or at surfaces was demonstrated by phase contrast microscopy when Cuprophane or PVC pretreated with thrombin and carefully rinsed was incubated in a fibrinogen solution. This fibrin formation is time dependent and likely is the result of direct interaction of adsorbed thrombin with fibrinogen in solution. Glass, Cuprophane, and PVC pretreated with thrombin were shown to attract more platelets than respective untreated surfaces. The enhancing effect of adsorbed thrombin on platelet adhesion was similar to the enhancing effect of adsorbed fibrinogen. Thrombin adsorbed onto PVC and crosslinked by glutaraldehyde treatment was shown to be antigenically active with a 125I-labeled monospecific antithrombin IgG produced in rabbits. No other plasma proteins adsorbed singly or from plasma or serum onto PVC reacted significantly with the antithrombin IgG preparation. The possible significance of these observations is discussed.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820140413
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  • 6
    Electronic Resource
    Electronic Resource
    An in vitro test system for estimation of blood compatibility of biomaterials (1974)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 8 (1974), S. 341-356 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: An in vitro test cell is described which permits exposure of artificial surfaces in sheet or film form to native human blood in the absence of a blood-air interface. Evaluation of Cuprophane, polyethylene, Silastic, and silicone-coated glass in the in vitro cell showed Cuprophane and silicone-coated glass to produce the least activation of the intrinsic coagulation system, while Silastic produced the greatest degree of activation. Polyethylene gave results intermediate between those obtained with the other materials. Each of these four different materials was evaluated in the elliptical cell test system multiple times with blood from 13 different donors.Our data suggest that with the present test system and the proper experimental design, one might expect that, “on the average,” performance of 36 tests on each of two materials will be sufficient for a 10% difference in their compatibility with blood to be statistically significant at the 5% level. The number of tests is 26 for significance at the 10% level.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820080602
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  • 7
    Electronic Resource
    Electronic Resource
    Some species differences in fibrinolysis and blood coagulation (1971)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 5 (1971), S. 121-128 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: The plasminogen levels and the reactivities of plasmas in two commonly used blood coagulation tests have been compared for man and seven mammals. The plasmas of three nonhuman primates in general reacted as did human plasma in tests for plasminogen activation and in reactivity in the partial thromboplastin time test. The dog had the highest level of plasminogen, and the goat the lowest, of the eight species tested. Overall, the pig appeared to have the most reactive blood coagulation mechanism, clotting the fastest and lysing the slowest, while man's was among the least reactive in clotting and intermediate in lytic activity of those tested. Aside from the nonhuman primates, the calf's clotting and lytic mechanisms resembled those of man more nearly than did those of the other mammals tested. The influence of these species differences on selection of animals for in vivo evaluation of blood vascular prosthetic materials and devices is discussed.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820050109
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    Paper (German National Licenses)
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  • 8
    Electronic Resource
    Electronic Resource
    High speed acquisition and data processing of peaks in the B-E plane of a double focusing mass spectrometer (1981)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 16 (1981), S. 507-511 
    Details
    ISSN: 0030-493X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A technique is described whereby a double focusing mass spectrometer is scanned under data system control to obtain a map of the intensity of the signal transmitted through the collector slit as a function of the electrostatic analyser and magnetic analyser field strengths. Results of processing programs are given, which allow various types of scans within the map to be extracted and presented.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/oms.1210161108
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    Paper (German National Licenses)
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  • 9
    Electronic Resource
    Electronic Resource
    Intervertebral disc degeneration in adult mice with hereditary kyphoscoliosis (1984)
    Hoboken, NJ [u.a.] : Wiley-Blackwell
    Journal of Orthopaedic Research 2 (1984), S. 333-338 
    Details
    ISSN: 0736-0266
    Keywords: Intervertebral disc ; Mouse mutant ; Kyphoscoliosis ; Life and Medical Sciences
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Breeding experiments confirmed that a hereditary form of kyphoscoliosis in the BDL strain mouse was due to an autosomal recessive gene (ky). Sagittal sections of whole vertebral columns from adult homozygous recessive mice (ky/ky) were examined histologically. All mice showed varying degrees of degenerative change in one or more intervertebral discs between the fifth cervical and the second thoracic vertebrae. The changes comprised loss of cells, loss of distinction between nucleus pulposus and annulus fibrosus, loss of characteristic ring-like structure in the annulus, and development of wedge-shaped discs. In most animals, degenerative disc substance protruded from the disc space, usually posteriorly, sometimes anteriorly, and occasionally through the vertebral end plate cartilage. Posterior protrusions impinged on the spinal cord.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jor.1100020405
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