Electronic Resource
Springer
Naunyn-Schmiedeberg's archives of pharmacology
325 (1984), S. 76-79
ISSN:
1432-1912
Keywords:
Kinins
;
Urate crystals
;
Uric acid
;
Inflammation
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary 1. Monosodium urate and uric acid crystals induced kinin formation in Wistar rat plasma. They were inactive in the Brown Norway rat plasma which did not contain high molecular weight kininogen and had a low level in prekallikrein. 2. Crystal-induced inflammation in the Brown Norway rat paw developed later and reached only 70% of the values observed in Wistar rats. Captopril, a kininase inhibitor, enhanced the oedema induced in the Wistar rat but did not affect the oedema in the Brown Norway rat. The leucocyte accumulation in the peritoneal cavity afte uric acid injection was similar in both strains. 3. The kinin system appeared to be involved in the inflammatory process induced in the rat by urate and uric acid crystals, as it is involved in carrageenan oedema.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00507057
Permalink
| Library |
Location |
Call Number |
Volume/Issue/Year |
Availability |
