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  • 1980-1984  (2)
  • 1965-1969  (1)
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Year
  • 1
    Electronic Resource
    Electronic Resource
    Mechanisms of passive sensitization (1965)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 250 (1965), S. 124-136 
    Details
    ISSN: 1432-1912
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00258552
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Modulation of histamine secretion from concanavalin A-activated rat mast cells by phosphatidyl serine, calcium, cAMP, pH and metabolic inhibitors (1980)
    Springer
    Inflammation research 10 (1980), S. 131-137 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Concanavalin A (con A) on its own released about half the histamine of peritoneal mast cells from three strains of rats. Phosphatidyl serine (PS) potentiated the release to about 80%. The secretory process had a calcium-independent component of 15–20% at pH 7.5, which increased to a maximum of 40% at pH 6.5 and nearly disappeared at pH 8.0. It was not affected by PS. In the presence of calcium and PS release was maximal and maintained at pH 7 to 8. Inhibitors of oxidative and glycolytic metabolism and dibutyryl cAMP (db cAMP) blocked secretion. The metabolic inhibitors were active whether or not PS was present, whereas db cAMP blocked much less effectively in the presence of PS. Dibutyryl cAMP reduced calcium uptake and this action was also impaired by PS. The active state induced by con A was relatively stable compared with that induced by antigen. Mast cells with a low response to anti-IgE also responded poorly to con A on its own, but con A plus PS was a highly effective stimulus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02024194
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    IgG receptors on the mast cell (1981)
    Springer
    Inflammation research 11 (1981), S. 77-83 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Antisera to the IgG subclasses, 1, 2a, 2b, and 2c, induced histamine release from mast cells obtained from the peritoneal washings of Lister hooded rats. The maximum responses obtained with anti-IgG1 and anti-IgG2a were as great as that for anti-IgE (more than 60% histamine release). Cells from unresponsive Wistar rats which did not secrete appreciable amounts of histamine in response to any of the antisera, produced on active sensitization with ovalbumin a small but significant response on challenge with anti-IgG1 and anti-IgG2b as well as with anti-IgE. Passive sensitization with rat myeloma serum of mast cells from the unresponsive rats produced a large response on challenge with anti-IgE but no release to the anti-IgG group 2 subclasses. IgE myeloma serum (1∶1000) neutralized the histamine-releasing activity of anti-IgE serum (87% inhibition) and the antisera to all subclasses of IgG. When the IgE in the myeloma serum was inactivated by heating, the response to the IgG antisera remained completely inhibited except for anti-IgG2a where some reversal was observed. When purified myeloma IgE (30 μg/ml) was used in place of whole serum, marked inhibition (86%) of the response to anti-IgE was obtained leaving the responses to the IgE subclasses unaffected (except for IgG2a, which was 65% inhibited).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01991464
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    Paper (German National Licenses)
    Fulltext
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