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  • 11
    Electronic Resource
    Electronic Resource
    The binding of steroid hormones and diethylstilbestrol to proteins of human cells in culture (1983)
    Springer
    Archives of toxicology 53 (1983), S. 245-248 
    Details
    ISSN: 1432-0738
    Keywords: Cell culture ; Diethylstilbestrol ; Estradiol ; Non-Steroidal synthetic estrogen ; Protein binding ; Steroid hormones ; Transplacental carcinogen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The binding of 3H-labeled steroid hormones and a non-steroidal synthetic estrogen, diethylstilbestrol (DES), to proteins of cultured human embryonic lung cells (HEL 299) was studied according to the methods of Diamond et al. [Cancer Res 27:890–897 (1967)] and Kuroki and Heidelberger [Cancer Res 31:2168–2176 (1971)]. Ecdysone, estradiol, hydrocortisone, progesterone, testosterone, and DES were selected as test compounds. The aim of this study was to determine the protein binding ability of DES, known as a transplacental carcinogen and teratogen for humans, and to compare it with those of the steroid hormones. DES was bound to proteins to the highest extent, and the amount of binding of estradiol was slightly lower than that of DES. Hydrocortisone, testosterone, and progesterone bound to proteins to smaller extents than DES and estradiol. Very little binding of ecdysone to cellular proteins was detected.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00316508
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  • 12
    Electronic Resource
    Electronic Resource
    Change in a bacterial population during the process of degradation of a phytoplankton bloom in a brackish lake (1983)
    Springer
    Marine biology 76 (1983), S. 253-255 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Change in a bacterial population during the process of degradation of a phytoplankton bloom was investigated at Lake Hamana, Japan in June 1981. The predominant phytoplankton were Prorocentrum micans Ehrenberg and P. triestinum Schiller. While most phytoplankton cells were living and moving actively, most bacteria were those in a free-living state (free-living bacteria) and the number of bacteria associated with particulate materials (attached bacteria) was less than a few percent of the total bacterial number. As the decline process proceeded, the number of free-living bacteria remained almost constant or decreased slightly; on the other hand, the number of attached bacteria increased gradually and reached about 40% of the total bacterial number. These results indicate that some of the free-living bacteria become attached to particulate organic matter and grow on the surface of the particles.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00393025
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  • 13
    Electronic Resource
    Electronic Resource
    Hormone receptors and obesity in Japanese women with breast cancer (1981)
    Springer
    Breast cancer research and treatment 1 (1981), S. 135-139 
    Details
    ISSN: 1573-7217
    Keywords: obesity ; estrogen receptor ; progesterone receptor ; Japanese women ; breast cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An association between hormone receptors in primary breast cancer and obesity determined prior to mastectomy was investigated in 128 Japanese women. The following criteria for obesity were used: (1) weight ≥60 kg (132 lbs), (2) weight kg/height cm−105 ≥ 1.3, (3) weight lbs/height in ≥2.30, (4) body surface area ≥1.56 m2. In view of the 4 criteria, tumor estrogen receptor (ER) values ≥ 4 fmol/mg were observed in obese patients more often than in nonobese patients, though the difference was not statistically significant. The same tendency was observed in the postmenopausal subgroup, 62 patients, especially in the 36 patients more than 5 years beyond menopause. However, there was still no statistical difference between obese and nonobese patients because the number of subjects was small. The same tendency was observed in the case of progesterone receptor (PgR) (≥6 fmol/mg) as observed in the case of ER.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01805867
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  • 14
    Electronic Resource
    Electronic Resource
    Evidence for a presynaptic action of chlordimeform at the insect neuromuscular junction (1983)
    New York, NY [u.a.] : Wiley-Blackwell
    Archives of Insect Biochemistry and Physiology 1 (1983), S. 33-39 
    Details
    ISSN: 0739-4462
    Keywords: insecticide chlordimeform ; neuromuscular junction ; transmitter release ; presynaptic spike ; postsynaptic potentials ; Tenebrio molitor ; mealworm ; Chemistry ; Food Science, Agricultural, Medicinal and Pharmaceutical Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: The mechanism of action of chlordimeform on the mealworm nerve-muscle preparation was studied with microelectrodes. Chlordimeform affected neither the mean amplitude nor the frequency of spontaneous miniature excitatory postsynaptic potentials. Extracellular focal recordings show that in the presence of 0.8 mM chlordimeform the presynaptic spike is almost unchanged, but the quantal content for evoked transmitter release is reduced. It is suggested that chlordimeform decreases the influx of calcium at the presynaptic terminal during the active phase of the nerve terminal action potential, thereby inhibiting evoked transmitter release.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/arch.940010105
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