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  • 1980-1984  (5)
  • 1960-1964  (3)
  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of medicinal chemistry 23 (1980), S. 729-734 
    ISSN: 1520-4804
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Analytical chemistry 33 (1961), S. 1112-1113 
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Several gold salts were compared in kaolin-induced rat paw oedema, u.v. erythema in guinea pigs, delayed type hypersensitivity and humoral immunity in mice, and adjuvant-induced arthritis in the rat. In the latter the additional parameters of serum gold and copper levels and lysosomal enzyme activity were determined. In addition, the in vitro inhibition of several lysosomal enzymes derived from mouse macrophages was studied. The gold compounds examined were aurothiomalate, aurothioglucose, triethylphosphine gold chloride (SK & F 36914) and its glucopyranoside derivative (SK & F D-39162), triphenylphosphine gold chloride and sodium gold chloride dihydrate. SK & F 36914 and SK & F D-39162 had significant activity after oral dosage upon paw kaolin and u.v. erythema in rats and guinea pigs, respectively. Gastric swelling also occurred. In Wistar rats, adjuvant arthritis was little affected by the gold salts but in the Lewis rats there was suppression. In both strains there was less elevation in serum copper levels with treatment by SK & F 36914 and SK & F D-39162, but not by aurothiomalate. None of the compounds had any measurable effect on delayed hypersensitivity or humoral antibody levels in mice. The in vitro activities of cathepsin B1 and cathepsin D were inhibited by all the gold compounds. Reactivity of gold dependent on compound solubility and the nature of the gold ligand. Considerable differences exist between the profiles of activity for the different gold salts evaluated. These observations indicate that some gold salts do possess anti-inflammatory activity with a potency similar to that of indomethacin.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Total serum copper and ceruloplasmin oxidase activities have been measured over a 24-h period in rats and guinea-pigs treated with 100 mg/kg body weight of copper (II) aspirinate. In the rat, administration s.c. produced higher total serum copper levels than oral administration at all time intervals studied, whereas in the guinea-pig, oral administration produced the higher level after 1 h and s.c. administration the higher level after 5 h. In both species, the rate of elimination of the additional copper was faster following oral administration. Ceruloplasmin oxidase activity appeared to be inhibited in certain cases but rose in all cases except for orally treated rats after 24 h. The initial rise in serum copper was due mainly to copper present on albumin. The increased albumin copper was detected directly by electrophoresis of serum samples and subsequent determination of the copper level in the portions of the strip which contained proteins. After s.c. administration to the rat, the amount of ultrafilterable copper was raised by a detectable amount. 7 h after s.c. or oral administration of copper aspirinate, the thiol concentration of the serum was reduced in both rats and guinea-pigs. The relationship of these levels to the anti-inflammatory action of copper(II) aspirinate in rats and guinea-pigs is discussed.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Rheumatology international 2 (1982), S. 107-111 
    ISSN: 1437-160X
    Keywords: Thiol ; Rheumatoid arthritis ; Sulphydryl ; Thiol reactivity ; Glutathione
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The thiol status of patients with rheumatoid arthritis is significantly different from that of controls. Plasma thiol levels are lower, albumin thiol reactivity is altered and intracellular thiol levels measured after hemoglobin precipitation are increased. These variations correlate with other indices of disease severity and are one measure of a disturbance in the degree of oxidation of the blood. Penicillamine, in common with other effective therapeutic agents, produces an increase in serum thiol concentration. It causes a greater effect on serum thiol reactivity than other drugs and in particular it increases ‘fast reacting’ thiol levels without significantly altering the ‘slow reacting’ thiol level.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Boundary layer meteorology 29 (1984), S. 185-210 
    ISSN: 1573-1472
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract The influence of some simple modifications to the physical parameterizations in the current GLAS climate GCM is examined. The aim of these modifications was to eliminate strong occasional bursts of 2 - δt oscillations in the PBL fluxes. The PBL of the current GLAS climate model was modified by invoking concepts of ensemble averaging of PBL eddies in a grid cell of the GCM. This resulted in smoothly varying bulk aerodynamic friction and heat transport coefficients. An arbitrary function to account for diffusion of moisture from stomatal cavities found in vegetation was also incorporated. Simultaneously some modifications to the cloud parameterizations were made. Two integrations, one with the old model and the other with the modified model, were made to simulate 47 days, starting from the NMC analysis for June 15, 1979. Their comparisons showed that the surface fluxes and cloudiness in the modified model simulations are far better. The planetary albedo in the modified model is also realistic. However, some weaknesses still persist, including an ITCZ (Inter-tropical convergence zone) that is too far northward in Sahelian Africa, polar regions that are too cold, and a rather strong ITCZ. It is pointed out that these weaknesses are primarily caused by model deficiencies, e.g., the cloud parameterization and the uniformly prescribed land surface roughness height. In another simulation with the modified model using a realistic value of surface roughness for deserts, the precipitation in the Sahara Desert reduced significantly, which effectively pushed the ITCZ southward to a more realistic location as compared to observations.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Hoboken, NJ : Wiley-Blackwell
    Journal of Polymer Science 48 (1960), S. 17-25 
    ISSN: 0022-3832
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Promoted preformed solids catalyze polymerization of ethylene and propylene and formation of copolymers of ethylene with such olefins as propylene and butene-1. The structure of the copolymers helps explain how they are formed and their properties. Kinetic studies alone do not distinguish between polymerization mechanisms involving either anionic centers or ion-radicals. Structural studies of ethylene-propylene copolymers of low propylene content show that they contain isolated propylene units in accord with the ion-radical theory of polymerization in a chemisorbed layer. Isolated short sidechains, so introduced, reduce density and increase flexibility. They give copolymers with flow properties more like those of linear polyethylenes than those of branched polyethylenes with long sidechains. Furthermore, they interfere with recrystallization and crystal growth; the resulting polymers have better stress-crack resistance and form clearer films.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Hoboken, NJ : Wiley-Blackwell
    Journal of Polymer Science 61 (1962), S. 39-44 
    ISSN: 0022-3832
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Copolymers of ethylene and C14-labeled propylene were prepared with a metal-oxide catalyst which polymerizes ethylene to a high density polymer. Methyl branches arising from the propylene were counted radiochemically and then related to the infrared absorption of films at 8.7 μ. This band was then used independently to determine methyl branching of a series of ethylene-propylene copolymers that differed in density and stiffness. Both properties decrease in value with an increase in branching.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
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