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  • 1980-1984  (2)
  • 1935-1939
  • Pancreatic secretion  (1)
  • Peptic ulcer  (1)
  • 1
    Electronic Resource
    Electronic Resource
    General and selective inhibition of pancreatic enzyme discharge using a proteinase inhibitor (FOY-305) (1984)
    Springer
    Journal of molecular medicine 62 (1984), S. 406-411 
    Details
    ISSN: 1432-1440
    Keywords: Pancreatic secretion ; Intracellular transport ; Proteinase inhibitor ; Two-dimensional gel electrophoresis ; FOY-305
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The guanidino acid esters (FOY, FOY-305) represent a new class of potent proteinase inhibitors and are thought to have a beneficial effect on the course of acute pancreatitis. Because of their structure and low molecular size they might enter cells and interfere with cellular processes. To test this possibility in the case of the exocrine pancreas a series of in vivo and in vitro studies was carried out to analyse intracellular transport and discharge of pancreatic enzymes in the presence of FOY-305. The infusion of FOY-305 to conscious rats led to a transient inhibition of protein and enzyme discharge from the cannulated pancreas accompanied by lower serum enzyme levels and increased enzyme content in the pancreas. An identical inhibition of discharge of newly synthesized proteins was observed in vitro in the presence of 1 µM FOY-305. The analysis of the release of individual enzymes using separation on two-dimensional gels showed a pronounced inhibition of mainly the release of acidic proteins. FOY-305 not only interfered with discharge of serine proteinases (trypsinogen, chymotrypsinogen, proelastase) but also with procarboxypeptidases and lipase. It was concluded that FOY-305 enters the acinar cell and due to an unspecific binding to acidic proteins interferes with the intracellular transport of individual enzyme proteins during their passage through the membrane-bound cellular compartments. This charge-dependent effect is independent of the inhibitory effect on enzymatic activity of serine proteinases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01742297
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    70a. Die Ulcusblutung — wann operative Blutstillung? (1984)
    Springer
    Langenbeck's archives of surgery 364 (1984), S. 381-385 
    Details
    ISSN: 1435-2451
    Keywords: Peptic ulcer ; Bleeding ; Surgical treatment ; Peptisches Ulcus ; Blutung ; Operation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Unter Berücksichtigung des natürlichen Verlaufs, epidemiologischer Befunde und prognostischer Faktoren ergeben sich folgende Indikationen zur operativen Blutstillung: 1. Sofortige Operation bei aktiver „unkontrollierbarer”, d. h. arterieller Blutung. Gelingt eine endoskopische Blutstillung, dann früh-elective Operation. 2. Frühelektive Operation bei Patienten mit persistierender venöser Sickerblutung, wenn mehr als 2500 ml Blut innerhalb von 24 h benötigt werden oder wenn nach 48 h frisches Blut im Magen nachweisbar ist. Dies gilt im besonderen für ältere, operable Patienten mit initial schwerer Blutung.
    Notes: Summary Considering natural history, epidemiology and prognostic criteria bleeding peptic ulcers should be operated: 1) in case of active “uncontrolled” bleeding: emergency operation. If bleeding is controlled by laser coagulation or sclerotherapy: early-elective operation. 2) in case of capillary persistent bleeding, blood loss of more than 2500 ml/24 h or continuous bleeding after 48 h: early-elective operation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01823239
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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