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  • 1980-1984  (2)
  • 1930-1934
  • Affective disturbances/etiology  (1)
  • Ehrlich ascites tumor  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Experimental investigations on a sequential combination chemotherapy protocol (1980)
    Springer
    Journal of cancer research and clinical oncology 96 (1980), S. 65-78 
    Details
    ISSN: 1432-1335
    Keywords: Ehrlich ascites tumor ; Proliferation kinetics ; Partial synchronization ; Combination chemotherapy ; Cytostatic drugs ; Adriamycin ; Hydroxyurea ; Vincristine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary This paper deals with experimental investigations concerning the composition of a cytostatic three-drug-protocol in diploid Ehrlich-Ascites-Tumor (EAT) cells in vivo at a far advanced stage of the disease. Hydroxyurea (HU) and vincristine (VCR) were used in very low doses to induce a modification of the growth pattern of tumor cells alike partial synchronization. Adriamycin (ADM) was selected as cytocidal drug during DNA synthesis of the partially synchronized cells. It was found that the sequential combination of HU and VCR (first HU and 12h thereafter VCR) caused the greatest alteration of growth pattern compared with other combination protocols. A further statistically significant increase of the degree of synchrony was observed after a second VCR administration—22 h after HU. By means of this protocol the EAT was subdivided into two proliferating subpopulations, a diploid and a tetraploid one. the tetraploid population resulted from surviving cells being not able to perform cytokinesis correctly, so that polynuclear cells and cells with a large single nucleus containing tetraploid DNA values were created. With respect to therapy, the administration of ADM at the time of DNA synthesis of the partially synchronized cells resulted in a statistically significant prolongation of the mean survival time and in 30% of cures of the animals. The dosage of ADM was 2.6 mg/kg, i.e., a nonlethal dose (50% of the LD10). Other combinations, i.e., simultaneous or reversed sequential combinations, did not show any therapeutic improvement compared to single drug therapy of ADM.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00412898
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  • 2
    Electronic Resource
    Electronic Resource
    Psychopathometrie depressiver Verstimmungen bei chronischer Hämodialyse (1981)
    Springer
    European archives of psychiatry and clinical neuroscience 230 (1981), S. 339-349 
    Details
    ISSN: 1433-8491
    Keywords: Haemodialysis ; Depression/etiology ; Affective disturbances/etiology ; MMPI/comparative study ; Human ; Hämodialyse ; Depression/Ätiologie ; Stimmungsschwan ; kungen/Ätiologie ; MMPI/vergleichende Studie ; Mensch
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 32 ambulante Hämodialyse-Patienten wurden über einen Zeitraum von 8 Tagen mehrfach täglich durch psychometrische Fremd- und Selbstbeurteilungsskalen in ihrer Befindlichkeit eingeschätzt. Ziel der Untersuchung war es, depressive Verstimmungen in ihrer Häufigkeit und Ausprägung bei Hämodialyse-Patienten zu erfassen. Es sollte zudem geprüft werden, inwieweit derartige depressive Verstimmungen zur Frage der biochemischen Determiniertheit von depressiven Syndromen beitragen können. Es fanden sich subjektiv erlebte kurzfristige depressive Stimmungsschwankungen in etwa 15% der Fälle, die in den psychometrischen Fremdbeurteilungen jedoch nicht zu objektivieren waren. Derartige depressive Verstimmungen sind somit als „Modelldepression“ für die biologische Depressions-Forschung nicht geeignet. Geringe Häufigkeit und Schwere der depressiven Verstimmungen, sowie psychopathologischer Längs- und Querschnitts-befund lassen die Hämofiltration als wesentlichen Depressionsfaktor im Sinne der Katecholamin-/Indolamin-Mangel-Hypothese unwahrscheinlich erscheinen.
    Notes: Summary Over a period of 8 days, 32 haemodialysis out-patients were studied. Psychometric alien- and self-rating questionnaires were completed twice a day. The aim of the study was to produce a survey of the frequency and severity of depression in haemodialysis patients. It was speculated that the potency of haemodialysis in producing depression might be a helpful model in searching for biochemical factors in this disorder. Self-ratings showed short-term depressive changes in mood in about 15% of cases, which were not confirmed by alien-rating scales. It is concluded that neither incidence and severity nor longitudinal and cross-sectional profiles support a biochemical determination of depression in haemodialysis patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00346105
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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