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  • 1980-1984  (4)
  • 1915-1919
  • somatotrophic diabetes  (2)
  • Bufo marinus  (1)
  • Competitive release  (1)
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Years
Year
  • 1
    ISSN: 1432-0428
    Keywords: Growth hormone ; somatotrophic diabetes ; metasomatotrophic diabetes ; hyperinsulinaemia ; hypoinsulinaemia ; insulin content of pancreas ; insulin responses to glucose ; glucagon ; arginine ; meals
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Growth hormone treatment produced somatotrophic diabetes, with hyperglycaemia, polyuria, glycosuria and elevation in serum non-esterified fatty acids (NEFA) in dogs. Early in this diabetes, fasting serum immunoreactive insulin (IRI) rose 20-fold, the insulin/glucose (I/G) ratio rose 10-fold and in response to glucose infusion, the rise in IRI was twice the normal. In the latter half of the continued growth hormone treatment, the intensity of the diabetes increased, serum IRI declined to the normal level and the I/G ratio became subnormal. Late in the treatment, following glucose infusion, there was no change in serum IRI, no fall in NEFA and further depression of glucose tolerance. In metasomatotrophic diabetes, in which hyperglycaemia, glycosuria and high NEFA level persisted, fasting serum IRI was normal during several months, then became subnormal and the I/G ratio was diminished further. Following glucose IV there was no change in serum IRI, no fall in NEFA and low glucose tolerance. The normally-occurring rises in serum IRI following arginine and glucagon IV and after the ingestion of a meal were absent. These permanently diabetic dogs were responsive to insulin IV. The insulin content of the pancreas was reduced to about 1.2% of the normal after 14 months of this diabetes. From the sequence of change it is concluded that growth hormone induced metasomatotrophic diabetes by causing excessive secretion of insulin under basal and stimulative conditions, leading to permanent loss of function of the beta cells of the pancreatic islets, to such an extent that basal insulin secretion was low and the ability to secrete extra insulin in response to stimuli was lost.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-0428
    Keywords: Growth hormone effects ; somatotrophic diabetes ; metasomatotrophic diabetes ; hyperinsulinaemia ; hyperproinsulinaemia ; hypoinsulinaemia ; pancreatic insulin and proinsulin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In normal fasting dog serum, the insulin: proinsulin molar proportion was 71:29%. In response to glucose infusion, the proinsulin proportion decreased. In the pancreas, the proinsulin proportion was lower than in serum. Growth hormone treatment for one day increased serum insulin sevenfold and proinsulin 18-fold. The proinsulin proportion increased to 49%. The growth hormone injections magnified the response to glucose infusion. The rise in serum insulin was 16 times the normal, proinsulin also rose but its proportion decreased. Growth hormone treatment for 6 days decreased pancreatic insulin to 5% and proinsulin to 46% of normal. In the permanent (metasomatotrophic) diabetes produced by the prolonged administration of growth hormone, serum insulin decreased and the proinsulin proportion increased. No rises in serum insulin nor proinsulin occurred following glucose infusion. In the pancreas, insulin and proinsulin were reduced to 1.6% and 8% of normal. The reduction in the immunoreactive insulin of the pancreas was more pronounced in the tail than in the head and body regions. The results indicate that in the state of augmented insulin secretion and hyperinsulinaemia produced by growth hormone and in the reduced insulin secretion and hypoinsulinaemia of metasomatotrophic diabetes, the proportion of proinsulin in serum is increased due to beta cell secretion containing a higher proportion of proinsulin than normal.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-0878
    Keywords: Carotid labyrinth ; Smooth muscle ; Intervascular stroma ; Bufo marinus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The amphibian carotid labyrinth consists of a pars cavernosa, the main chamber of which is in communication with both the base of the external carotid artery, and the vessels of the labyrinthine pars capillaris. On the walls of the main chamber is a network of thick strands of connective tissue and modified smooth muscle cells surrounding the openings into the p. capillaris. These openings lead into wide-diameter atrial vessels, which in turn branch to form the short narrow-diameter vessels. The short vessels form the major component of the labyrinth. A few extremely narrow-diameter vessels are also present. The short vessels open into the roots of the internal carotid artery on the ventral aspect of the carotid labyrinth. The intervascular stroma of the p. capillaris contains numerous stellate and bipolar cells. These cells give a positive response to an immunofluorescent technique specific for smooth muscle myosin and tropomyosin. As the ultrastructural features of these cells are comparable in many respects to smooth muscle, they have been designated as modified smooth muscle cells. It is proposed that these cells act in both an active and passive fashion in maintaining the luminal dimensions of the short vessels relatively constant.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Plant ecology 49 (1982), S. 85-101 
    ISSN: 1573-5052
    Keywords: Competitive release ; Dispersal ; Eastern North America ; Europe ; Extinction ; Habitat gradients ; Niche ; Temperate forests
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Major dimensions of ecological segregation of tree species in cool temperate Europe and E North America appear related to (a) soil pH, (b) large scale ‘succession’ including topographic sequences of changing moisture stress, and (c) intolerance versus tolerance of canopy competition as involved in ‘gap-phase’ dynamics. Genera tend to have similar average positions along these dimensions in the two subcontinents. E North American genera that were probably never present in Europe, and the few opposites, tend to be southern and are concentrated on dry or basic soil. The cause of this trend may involve the isolated expansions of dry climatic areas since the early Tertiary. E North American genera that became extinct in Europe after the mid-Pliocene are typical of habitat intermediate between dry-acid and moist-basic, though generally more moist-acid than dry-basic. These genera also have few species and little overall habitat width. Severe restrictions of their habitats may have occurred. Also, difficulties of migration to and from refugia are suggested by the generally heavier seed of extinet genera and those with strongly southern ranges in Europe or with few species compared to E North America. This relationship is apparent within small winged, medium fleshy and large nutty fruit classes. However, there is little difference in geographic restriction between these classes. Carpinus, Alnus, Corylus, Taxus, Pyrus and Sorbus reach 100–1000% greater height in Europe. There are no opposing differences of this magnitude. These trees may be ecological substitutes for extinct Liriodendron, Liquidambar, Carya, Tsuga + Thuja, Diospyros, and a group with smaller fleshy fruits, respectively. There are other intrageneric differences in height, seed weight, niche width, longevity, etc., that deserve further attention.
    Type of Medium: Electronic Resource
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