ISSN:
1434-9949
Keywords:
Rheumatoid Arthritis
;
Renal Tubular Injury
;
Gold Related Nephropathy
;
ß-2-Microglobulin
;
N-Acetyl-B-D-Glucosaminidase
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The urinary excretion of two proteins, B-2-microglobulin (ß2M) and N-acetyl-B-D-glucosaminidase (NAG) was measured in 25 patietns with rheumatoid arthritis (RA) on nonsteroidal anti-inflammatory drugs (NSAID). Although ß2M excretion was normal NAG excretion was raised. As NAG excretion by a group of osteoarthritis patients receiving similar doses of NSAIDs was normal, it is concluded that rheumatoid disease per se may be associated with mild renal tubular dysfunction. Twelve of the above 25 patients were then given oral triethylphosphinegold (auranofin) 6 mg daily and urinary ß2M and NAG were meaured after 6 months' treatment. Urinary excretion of ß2M and NAG was also measured in 13 patients with RA established on intramuscular sodium aurothiomalate (MGST) and NSAIDs. Neither auranofin nor myocrisin were found to further significantly increase ß2M and NAG excretion. These results suggest that gold compounds are not toxic to renal tubular epithelium.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02041402
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