ISSN:
0942-0940
Keywords:
Cerebral ischaemia
;
mannitol
;
fluorocarbon emulsion
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Using the “canine model of complete ischemic brain regulated with a perfusion method” in which it is possible to control the degree of blood flow to a cerebral hemisphere via a perfusion pump, the effects of mannitol (which acts as a free radical scavenger) and fluorcarbon emulsion (FC) (which has 0.1 μm of average particle size and a high oxygen-carrying capacity) on cerebral ischaemia were investigated. After pretreatment with the drugs, blood flow was reduced via the pump to 1/10 the normal state and 1 hour later, return to a normal state allowed. Subsequent changes in electrical activity were observed and the effects of the drugs evaluated. In the control group, no recovery of electrical activity was seen, but in the animals treated with either mannitol or FC, incomplete, yet distinct recovery was apparent. In the animals administered mannitol together with FC, however, marked recovery was evident. These experimental results indicate that the combined administration of mannitol and FC is effective in protecting the brain from cerebral ischaemia.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01407227
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