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  • 1980-1984  (2)
  • 6-Hydroxydopamine  (1)
  • Complex cyanotic heart disease  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Psychopharmacology 79 (1983), S. 115-119 
    ISSN: 1432-2072
    Keywords: Dopamine ; Acquisition ; Brain lesions ; 6-Hydroxydopamine ; Neonatal rat ; Operant behavior
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In an attempt to examine the ability of brain dopamine (DA) depletion to alter learning ability in the developing rat, the rate of acquisition of a positively reinforced lever pressing response was examined in rats during days 30–45 of life following treatment with desmethylimipramine (DMI, 20 mg/kg IP) and 6-hydroxydopamine (6-OHDA, 35 μg intraventricularly) at 3 and 6 days of age, respectively. The 6-OHDA treatment produced a 40%–70% reduction of brain DA without altering growth rate, water intake, or locomotor activity. On the average, water-deprived control rats achieved the criterion for acquisition (50 reinforced lever presses/h) on a fixed-ratio 1 schedule of water reinforcement after 3.1±0.5 sessions (mean ± SEM). In contrast, nearly one-fourth of the DMI + 6-OHDA-treated rats failed to acquire the response after 16 sessions and the remaining 6-OHDA-treated rats required more than twice as long as controls for acquisition (7.8±0.7 sessions). These results suggest that brain DA depletion in neonatal life can impair the acquisition of an operant response during development and that this deficit is independent of changes in growth rate or locomotor activity.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1971
    Keywords: Dextrocardia ; Polysplenia ; Complex cyanotic heart disease ; Surgery ; Intra-atrial baffle
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The clinical, angiocardiographic, and surgical findings in a cyanotic child with dextrocardia, L-loop, laterally inverted but otherwise normally related great arteries, and situs ambiguus are described and compared with other similar cases. Electrocardiographic, echocardiographic, and angiographic data are reviewed, and thesegmental approach to diagnosis is stressed. Both systemic and pulmonary veins returned to the right-sided atrium. Blood then passed either through the mitral valve to the morphologically left ventricle and to the aorta or through an atrial septal defect to a small left-sided atrium, right ventricle, and pulmonary artery. Total correction was undertaken with an intra-atrial baffle to direct pulmonary venous return to the morphologically right ventricle and systemic venous return to the right ventricle. The subpulmonic stenosis was alleviated with an outflow patch.
    Type of Medium: Electronic Resource
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