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  • 1980-1984  (2)
  • Acetylcholine  (1)
  • Ketanserin  (1)
  • Serotonin  (1)
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  • 1980-1984  (2)
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  • 1
    Electronic Resource
    Electronic Resource
    The effect of tryptamine on serotonin release from hypothalamic slices is mediated by a cholinergic interneurone (1982)
    Springer
    Psychopharmacology 78 (1982), S. 85-88 
    Details
    ISSN: 1432-2072
    Keywords: Hypothalamus ; Serotonin ; Tryptamine ; Acetylcholine ; Release ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Tryptamine produced a concentration-related inhibition of potassium-evoked release of tritium from slices of rat hypothalamus preloaded with 3H-serotonin. This effect of tryptamine was blocked by a series of serotonin antagonists with a relative order of potency which suggested that tryptamine was acting on a post-junctional serotonin receptor. However, the response to tryptamine was also blocked by tetrodotoxin, indicating that tryptamine may be acting indirectly via the release of a second neurotransmitter. The finding that physostigmine enhanced, whilst atropine antagonised the effect of tryptamine suggests that the second neurotransmitter may be acetylcholine. This possibility is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00470595
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Evidence that 5-HT agonist-induced rotational behaviour in the rat is mediated via 5-HT1 receptors (1984)
    Springer
    Psychopharmacology 83 (1984), S. 163-165 
    Details
    ISSN: 1432-2072
    Keywords: Supersensitivity ; 5-HT1 receptors ; Methysergide ; Ketanserin ; Pirenperone ; 5-HT agonist rotational behaviour ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The rotational behaviour induced by 5-HT agonists has been investigated in rats with lesions of the dorsal raphe' nucleus (DRN). We have previously reported that 5-methyoxy-N,N-dimethyl-tryptamine (5-MeODMT) caused dose-related contralateral rotation in rats with 5,7-dihydroxytryptamine (5,7-DHT) lesions of the DRN. Similar findings are now presented for the 5-HT1 agonists 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) and 5-methoxy-3 (1,2,3,6-tetrahydropyridin-4-yl) (1H indole) (RU24969). In this model, in agreement with the behavioural studies, both agonists were shown to have a greater affinity for the 5-HT1 binding site when compared with the 5-HT2 binding site. Antagonist studies using selective 5-HT2 antagonists (ketanserin and pirenperone) at non-sedative doses failed to inhibit this behaviour. In contrast, the classical 5-HT antagonist methysergide caused significant inhibition of the rotational behaviour. These results suggest that 5-HT agonist-induced rotation in the rat is mediated via 5-HT1 receptors, probably located in the substantia nigra.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00429727
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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