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  • 1980-1984  (3)
  • Acid  (1)
  • Blood-brain barrier  (1)
  • Liver damage  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Alterations in neutral amino acid transport across the blood-brain barrier in hepatic failure (1983)
    Springer
    Research in experimental medicine 183 (1983), S. 11-18 
    Details
    ISSN: 1433-8580
    Keywords: Blood-brain barrier ; Neutral amino acid ; Hepatic failure ; Amino acid transport into the brain
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The accelerated transport of the blood neutral amino acids into the brain in encephalopathic patients with fulminant hepatitis and advanced liver cirrhosis was demonstrated not only by determining the cerebrospinal fluid (CSF) aminogram but also by calculating the predicted velocity of the amino acid transport through the blood-brain barrier. Significant elevation in CSF aromatic amino acid (AAA) and methionine levels was observed in the encephalopathic patients. Arousal from hepatic encephalopathy by drip infusion of a branched chain amino acid (BCAA)-enriched solution was obtained coincidentally with the elevated BCAA levels and diminished concentrations of AAA and methionine in CSF. These clinical observations were confirmed experimentally in rats treated with carbon tetrachloride (CCl4) andd-galactosamine by obtaining the elevation of neutral amino acid contents in the brain and the slight increase in the brain uptake index (BUI) of a radiolabeled amino acid.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01851759
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Pleomorphism of hepatic regeneration (1984)
    Springer
    Research in experimental medicine 184 (1984), S. 49-57 
    Details
    ISSN: 1433-8580
    Keywords: Hepatic regeneration ; Partial hepatectomy ; Liver damage ; Repair of liver damage ; CCl4
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The pleomorphism of hepatic regeneration was studied in acute liver injury and partial hepatectomy of rats. Increases in3H-thymidine incorporation into the liver DNA fraction and in liver ornithine decarboxylase (ODC) activity were observed similarly in acute liver injury and following a two-thirds partial hepatectomy in normal rats. However, the increase in serum AFP levels was significant only in carbon tetrachloride (CCl4)-treated rats, and the portal-peripheral vein difference in plasma glucagon concentrations was great only in rats that underwent a partial hepatectomy. The weight of the remaining liver increased rapidly following a 67% hepatectomy in normal rats, but not in cirrhotic rats, of which three of five died within 6 days. Increases in liver prostaglandin E levels,14C-orotate incorporation into the liver RNA fraction and hepatic ODC activity were observed up to 10 h following a partial hepatectomy of normal liver but not after similar removal of cirrhotic liver. Three kinds of hepatic regeneration, i.e., normal and pathologic regeneration following surgical removal of either normal or injured liver and repair of liver damage following chemically induced liver deficiency, were proposed from the observations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01852222
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Microdisc-electrophoretic study of deoxyribonucleases in cow snout epidermis (1983)
    Springer
    Archives of dermatological research 275 (1983), S. 213-217 
    Details
    ISSN: 1432-069X
    Keywords: Acid ; Neutral DNases ; Epidermis ; Microdisc ; Electrophoresis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Acid and neutral deoxyribonucleases (DNases) of the cow snout epidermis were investigated by the microdiscelectrophoresis of polyacrylamide gels containing highly polymerized DNA and by isoelectric focusing techniques. The nucleases were characterized with respect to their pH optimum. An acid DNase at pH 5.0 was detected as a single distinct band after the electrophoretic separation. After isoelectric focussing also, only one acid DNase activity with an isoelectric point (IP) of 6.2 was detectable. Neutral DNases at pH 7.4 were demonstrated as major and minor bands by their different electrophoretic mobilities. In the isoelectric focusing system also, two neutral DNases, a major one (IP, 4.6) and a minor one (IP, 6.4), were found. Characterization with respect to their histologic location showed acid and neutral DNases across the epidermal layers with the highest activities in the upper layers, where DNA concentration had been shown to be lowest. In correlation with their subcellular distribution, the highest activities of both acid and neutral DNase were found in the 105,00xg supernatant of the subcellular fractions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00416662
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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