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  • 1
    Electronic Resource
    Electronic Resource
    Corticosteroid response to stress depends upon increased tryptophan availability (1983)
    Springer
    Psychopharmacology 79 (1983), S. 79-81 
    Details
    ISSN: 1432-2072
    Keywords: Corticosteroid response to stress ; Tryptophan availability ; Amino acids ; 5HT synthesis ; Tryptophan ; Tyrosine ; Valine ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Prior administration of valine to rats has been shown previously to prevent restraint stress-induced increases in brain tryptophan and 5HT turnover. The present study demonstrates that the accompanying attenuation of the corticosteroid response to this stress is substantially reversed by administration of tryptophan with the valine. Tyrosine is not effective in reversing this attenuation, and in fact itself attenuates the corticosteroid response to the stress when given alone. It is concluded that at least part of the corticosteroid response to restraint stress is mediated by an increase in serotonergic activity that is dependent on increased supply of the precursor, tryptophan, and that this can be antagonised by either of two amino acids which compete with tryptophan for access to the brain. Implications for stress-associated human disorders are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00433020
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  • 2
    Electronic Resource
    Electronic Resource
    Metabolism of the lignin model compounds veratrylglycerol-β-guaiacyl ether and 4-ethoxy-3-methoxyphenylglycerol-β-guaiacyl ether by Phanerochaete chrysosporium (1980)
    Springer
    Archives of microbiology 125 (1980), S. 227-231 
    Details
    ISSN: 1432-072X
    Keywords: Phanerochaete chrysosporium ; Lignin model compounds ; β-aryl ether dimers ; Metabolism αβ cleavage ; Veratryl alcohol ; 4-ethoxy-3-methoxybenzyl alcohol ; Alkyl-phenyl cleavage
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The white rot fungus Phanerochaete chrysosporium metabolized the lignin model compounds veratylglycerol-β-guaiacyl ether I and 4-ethoxy-3-methoxy-phenylglycerol-β-guaiacyl ether V in stationary culture under an atmosphere of 100% oxygen and under nitrogen limiting conditions. 2-(o-methoxyphenoxy)-ethanol VII was identified as a product of the metabolism of both substrates. Veratryl alcohol and 4-ethoxy-3-methoxybenzyl alcohol IV were identified as metabolites of I and V respectively. Metabolites were identified after comparison with chemically synthesized standards by mass spectrometry. These results indicate the existence of an enzyme system capable of directly cleaving the etherated dimers I and V at the α, β bond. The additional identification of 2-(o-methoxyphenoxy)-1,3 propanediol IX as a metabolic product indicates that cleavage of the alkyl-phenyl bond of these dimers or their metabolites also occurs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00446881
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  • 3
    Electronic Resource
    Electronic Resource
    β-Ether cleavage of the lignin model compound 4-ethoxy-3-methoxyphenylglycerol-β-guaiacyl ether and derivatives by Phanerochaete chrysosporium (1981)
    Springer
    Archives of microbiology 129 (1981), S. 141-145 
    Details
    ISSN: 1432-072X
    Keywords: Phanerochaete chrysosporium ; Lignin model compounds ; Lignin metabolism ; β-aryl ether dimers ; β-ether cleavage
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The white rot basidiomycete Phanerochaete chrysosporium metabolized 4-ethoxy-3-methoxyphenyl-glycerol-β-guaiacyl ether (V) in low nitrogen, stationary cultures under which conditions the ligninolytic enzyme system is expressed. 4-Ethoxy-3-methoxyphenylglycerol XIII, guaicol and 4-ethoxy-3-methoxybenzyl alcohol (II) were isolated as metabolic products. Exogenously added XIII was rapidly converted to 4-ethoxy-3-methoxybenzyl alcohol indicating that it is an intermediate in the metabolism of V. P. chrysosporium also metabolized 1-(4′-ethoxy-3′-methoxyphenyl)-2-(2″-methoxyphenoxy)-3-hydroxypropane VI. The degradation pathway for this dimer also included initial β-ether cleavage and α-hydroxylation of the diol product 1-(4′-ethoxy-3′-methoxyphenyl) 2,3 dihydroxypropane (XI) to yield the triol XIII which was cleaved at the α, β bond to yield 4-ethoxy-3-methoxybenzyl alcohol. Finally P. chrysosporium also cleaved the dimer 1-(4′-ethoxy-3′-methoxyphenyl)-2-(2″-methoxyphenoxy)-1-hydroxypropane (VIII) at the β-ether linkage yielding 1-(4′-ethoxy-3′-methoxyphenyl) 1,2 dihydroxypropane (IX) which was subsequently cleaved at the α, β bond to yield II. All of the results indicate that oxidative β-ether cleavage is an important initial reaction in the metabolism of β-aryl ether lignin substructure dimeric compounds. Metabolities were identified after comparison with chemically synthesized standards by gas liquid chromatography-mass spectrometry.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00455350
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Quantitative analysis of disaturated lecithins in human plasma by ammonia chemical ionization mass spectrometry (1981)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 8 (1981), S. 503-505 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Three physiologically important disaturated lecithins have been analyzed quantitatively as the acetate derivatives using a solids inlet probe and ammonia chemical ionization. Concentration independent response factors have been determined over a tenfold range that brackets human plasma levels. The results obtained serve as an independent corroboration of gas chromatographic analyses.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200081008
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  • 5
    Electronic Resource
    Electronic Resource
    Metabolism of 1,1,1,2,2-pentafluorohexane and 1,1-difluorocyclohexane by rat liver microsomes in vitro (1984)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 11 (1984), S. 512-521 
    Details
    ISSN: 0306-042X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Metabolism of 1,1,1,2,2-pentafluorohexane with liver microsomes from phenobarbital-treated rats gave only one metabolite, namely, the 5-hydroxy derivative. Under similar conditions 1,1-difluorocyclohexane was metabolized to give mainly the 3- and 4-hydroxy derivatives in the ratio 1:∼5.5 The structures of these metabolites were established by chemical ionization (CI) and/or electron impact (EI) mass spectrometry and confirmed by synthesis in the case of 1,1-difluorocyclohexan-4-ol. Oxidation of 1,1-difluorocyclohexane with lead tetrakis(trifluoroacetate) also gave, inter alia, the 3- and 4-hydroxy derivatives. In saturated hydrocarbons complete replacement of hydrogen by fluorine at one particular carbon will not only block microsomal hydroxylation thereat but will also inhibit hydroxylation at neighbouring hydrogen-bearing carbons, (α almost completely, β markedly, γ slightly).
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200111005
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  • 6
    Electronic Resource
    Electronic Resource
    Properdin factor B (Bf) distribution in North and Central American populations (1981)
    Weinheim : Wiley-Blackwell
    Electrophoresis 2 (1981), S. 320-323 
    Details
    ISSN: 0173-0835
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: A study of properdin factor B (Bf) in 22 North and Central American populations demonstrated gene clusters delineating Old World Caucasian, New World and Black Ancestoral groups. Result of gene frequencies were comparable to data in the literature of European Caucasian and African Blacks. New World indigeneous population were clearly separated from other racial groups with hybrid population clustering in between the major genetic contributions.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/elps.1150020512
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Polyacrylamide gel electrophoresis of small peptides (1984)
    Weinheim : Wiley-Blackwell
    Electrophoresis 5 (1984), S. 133-138 
    Details
    ISSN: 0173-0835
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Two polyacrylamide gel electrophoretic systems for the separation of small peptides are described. In both systems the samples are concentrated by a buffer discontinuity, and the peptides separated according to size and charge in 40-50 % polyacrylamide resolving gels. The acidic gel has an operative pH between 3.0 and 3.1 while the alkaline gel has an operative pH between 9.1 and 9.2. The lower limit of resolution is about 100 daltons for a peptide with one positive charge in the acidic system. The radioactive peptides are detected by autoradiography. Peptides with a free amino group can be fixed in these gels with formaldehyde, so that fluorographic procedures can also be used for increased sensitivity. These techniques enable precise comparison of non-derivatized peptides from complete protein fingerprints and offer a simple one-dimensional analytical method for protein comparison, as well as a general method for separating and analyzing small peptides.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/elps.1150050302
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