ISSN:
1432-2072
Keywords:
Amitriptyline
;
Antimuscarinic
;
Catecholamines
;
Positive chronotropy
;
Aging
;
Norepinephrine
;
Angina
;
Sinus heart rate
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Amitriptyline (AT) increases sinus heart rate (SHR) due to inhibition of the reuptake of norepinephrine in combination with an antimuscarinic blockade of cardiac vagal inhibition. After 150 mg/day AT for 28 days, the change in SHR was negatively correlated with age in 42 depressed patients who were 18–85 years of age. This finding is consistent with observations that the tachycardic response to antimuscarinics and catecholamines decreases with aging.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00427785
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