Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • 1980-1984  (5)
  • Analytical Chemistry and Spectroscopy  (3)
  • Phase II study  (2)
  • Organic Chemistry
  • 1
    Electronic Resource
    Electronic Resource
    Phase II study of Baker's antifol (triazinate, TZT, NSC 139, 105) in advanced carcinoma of the ovary (1983)
    Springer
    Investigational new drugs 1 (1983), S. 185-188 
    Details
    ISSN: 1573-0646
    Keywords: ovarian carcinoma ; Baker's antifol ; triazinate ; Phase II study
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Twenty-nine patients with advanced ovarian carcinoma were entered into a Gynecologic Group Phase II study of Baker's Antifol. Of these, 26 were eligible for evaluation of toxicity and 25 for evaluation of response. The evaluable patients constituted an unusually favorable group for a Phase II study in a chemotherapy-sensitive tumor; although all have received prior chemotherapy, eight had had treatment with only a single alkylating agent and the median performance status of the study population was two (ambulatory, capable of self-care). No complete responses were seen. Two patients had regression of abdominal tumor masses sufficient to qualify as partial responders (PR 8%). Dose-limiting toxicity, as expected, was found to be gastrointestinal. Significant mucositis and dermatitis were also observed. No episodes of hypotension during infusion occurred with a 60–120 min time of administration. Baker's antifol has only limited activity against ovarian carcinoma previously treated with chemotherapy and is not likely to contribute to improved therapy, either as a single agent or in combination.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00172079
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    A Phase II study of Bruceantin (NSC-165, 563) in advanced malignant melanoma (1983)
    Springer
    Investigational new drugs 1 (1983), S. 239-242 
    Details
    ISSN: 1573-0646
    Keywords: bruceantin ; Phase II study ; melanoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The Eastern Cooperative Oncology Group (ECOG) conducted a Phase II trial of Bruceantin in malignant melanoma. Twenty-two patients, thirteen without prior cytotoxic chemotherapy, were entered. All patients were evaluable for response and toxicity. Dose limiting toxicity was found to be hypotension during Bruceantin infusion. Other prominent side effects were nausea, vomiting, anorexia, fever, chills, and weakness. Only minor hematologic toxicity was encountered. Two partial responses, both in previously treated patients were observed (response rate — 9%). Bruceantin has only limited activity against malignant melanoma and is unlikely to contribute to systemic therapy of this disease, either as a single agent or in combinations of cytotoxic drugs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00208896
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Carbon-13 nuclear magnetic resonance spectra of ceveratrum alkaloids (1980)
    Chichester : Wiley-Blackwell
    Organic Magnetic Resonance 14 (1980), S. 141-144 
    Details
    ISSN: 0030-4921
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The 13C NMR spectra were determined and signals assigned to the various carbons of the alkamines veracevine, germine and zygacine derived from steroidal alkaloids of the ceveratrum class. Assignment of signals was aided by analysis of the partially relaxed spectrum of cervagenine 9,12,14-orthoacetate-3, 16-diacetate.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mrc.1270140213
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    The 13C NMR spectra of tallysomycin and its zinc(II) complex (1980)
    Chichester : Wiley-Blackwell
    Organic Magnetic Resonance 13 (1980), S. 270-273 
    Details
    ISSN: 0030-4921
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Using the carbon assignments of bleomycin A2 as well as those of a series of model compounds, the 13C NMR assignments of the antitumor antibiotic tallysomycin (TLM) have been made. With the aid of the carbon assignments the metal binding properties of the new antibiotic toward Zn(II) have been investigated.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mrc.1270130410
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Raman spectral studies of bleomycin A2 and related structural fragments: A probe for bleomycin-DNA interactions (1983)
    Chichester [u.a.] : Wiley-Blackwell
    Journal of Raman Spectroscopy 14 (1983), S. 266-270 
    Details
    ISSN: 0377-0486
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Raman spectra have been obtained for bleomycin A2 and selected fragments. Virtually all of the features in the bleomycin Raman spectrum can be attributed to the preresonance enhanced vibrational transitions of the 2,4′-bithiazole moiety as determined by comparison to the Raman spectra of bithiazole fragments. The Raman spectrum of bleomycin is dominated by a very intense band at 1542 cm-1 that can be approximately assigned as a bithiazole ring stretching mode. This feature may serve as a probe of bithiazole environment in bleomysin -DNA interactions.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jrs.1250140411
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...