ISSN:
1432-1335
Keywords:
Two-stage skin carcinogenesis
;
DMBA
;
TPA
;
4-O-Methyl-TPA
;
Melanosis
;
Melanomas
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The effect of the tumor promoter TPA and its inactive structural analogue 4-O-methyl-TPA on the induction of dorsal skin melanosis in the normal Syrian golden hamster and on the promotion of melanomas in DMBA-initiated animals was investigated. Both phenomena were observed in TPA-treated hamsters but could not be detected after exposure of animals to 4-O-methyl-TPA. In contrast to results obtained with a variety of other laboratory animals, neither TPA nor 4-O-methyl-TPA were able to induce epidermal hyperplasia of hamster dorsal skin.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00409706
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