ISSN:
1432-1076
Keywords:
3-Methylcrotonyl-CoA carboxylase
;
3-Hydroxyisovaleric acid
;
3-Methylcrotonylglycine
;
Biotin
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Two Vietnamese siblings with an isolated deficiency of 3-methylcrotonyl coenzyme A carboxylase in leucocytes and culture fibroblasts are described. Both children excreted massive amounts of 3-methylcrotonylglycine and 3-hydroxyisovaleric acid. There was no in vivo or in vitro biochemical response to biotin. Apart from an attack of vomitting leading to subcoma in the elder sib four weeks after arrival in the Netherlands, the children were in good health. There were no signs of delayed mental development.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00442517
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