ISSN:
0730-2312
Keywords:
DNA binding protein
;
polyoma virus
;
moddle-T
;
retroviruses
;
oncogenes
;
transforming proteins
;
SV40 large-T
;
Life and Medical Sciences
;
Cell & Developmental Biology
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Biology
,
Chemistry and Pharmacology
,
Medicine
Notes:
Cellular oncogenes and their activated and retrovirus-coded counterparts play an important role in cellular regulation. Here the relationship between such oncogenes and the genes coding for the transforming proteins of the papovaviruses, polyoma viruses, and simian virus 40 (SV40) is discussed. It is concluded that polyoma virus may transform established cells by a mechanism involving activation of a cellular oncogene product, whereas SV40 may transform by a mechanism involving a previously little studied cytoplasmic form of the transforming protein.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jcb.240260204
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