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  • 1
    Electronic Resource
    Electronic Resource
    An experimental evaluation of dependence liability of methaqualone diphenhydramine (combination) and methaqualone in rats (1980)
    Springer
    Psychopharmacology 67 (1980), S. 203-207 
    Details
    ISSN: 1432-2072
    Keywords: Methaqualone and diphenhydramine ; Methaqualone ; Tolerance ; Physical dependence ; Audiogenic seizures
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In the present study the drugs (Methaqualone + diphenhydramine or Methaqualone alone) were administered daily in a liquid diet to different groups of rats for 3 weeks. Each week the doses of the drugs were increased and daily records of body weight, mean rectal temperature and spontaneous motor activity (SPM) were maintained. During the first week, tolerance to both the drugs was observed when the animals received 152.4 mg/kg-1/day of methaqualone (MQ) and 140.0+14.0 mg/kg-1/day of methaqualone + diphenhydramine (MQ+D) respectively. In the second week the doses were further increased to 302.0 mg/kg-1/day of MQ and 277.8+27.7 mg/kg-1/day of MQ+D respectively. At the end of the second week complete tolerance developed to increased doses of MQ but not to the MQ+D combination. In the third week the doses were further increased to 406.6 mg/kg-1/day of methaqualone and 383.4+38.3 mg/kg-1/day of MQ+D respectively. At the end of this week although there was partial recovery but, compared to the controls, a significant lowering (P〈0.05) of mean rectal temperature and spontaneous motor activity persisted in both groups thus showing an incomplete tolerance to larger doses of both MQ and the MQ+D combination. When the drugs were withdrawn after the third week, both MQ as well as MQ+D treated groups of rats exhibited an increased susceptibility to audiogenic stimuli of, but MQ+D treated animals showed an even greater susceptibility to such stimuli and also a fall in body weight. Further, 50% of rats in MQ+D group died during convulsions while there were no deaths in the group treated with MQ alone. The results of this study suggest that the MQ+D combination causes a more severe degree of physical dependence than MQ alone.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00431978
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of dietary chronic cadmium exposure on cell-mediated immune response in Rhesus monkeys (Macaca mulatta): role of calcium deficiency (1984)
    Springer
    Archives of toxicology 56 (1984), S. 128-131 
    Details
    ISSN: 1432-0738
    Keywords: Cadmium ; Calcium ; Monkey ; Cell-mediated immune response ; Lymphocytes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The role of Ca deficiency on the immunomodulatory effects of chronic Cd exposure for a period of 10 weeks in male Rhesus monkeys were assessed by the blastogenic capacity of peripheral blood lymphocytes (PBL) in response to T-cell mitogens, phytohemagglutinin (PHA), and concanavalin A (Con A). Calcium deficiency significantly decreased the blastogenic response to PHA (P〈0.01) and Con A (P〈0.05). Although Cd exposure in normal monkeys significantly increased the blastogenic response to Con A (P〈0.05), Cd exposure in Ca-deficient monkeys produced a further significant decrease in the blastogenic response to Con A (P〈0.001). Total and ionic Ca were also significantly decreased in plasma of Ca deficient monkeys exposed to Cd. It is possible that these two observations may be related to each other. Thus, it is important to assess the nutritional status of the host while evaluating the immunotoxicological effects of an environmental pollutant.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00349085
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  • 3
    Electronic Resource
    Electronic Resource
    Heat and mass transfer in convective flow of an incompressible rarefied visco-elastic fluid in presence of transverse magnetic field (1983)
    Springer
    Astrophysics and space science 95 (1983), S. 439-451 
    Details
    ISSN: 1572-946X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Analytical study is performed to examine heat and mass transfer characteristics of natural convection flow of an incompressible, rarefied visco-elastic fluid past an infinite vertical porous plate with constant suction in the presence of transverse magnetic field under combined buoyancy force effects of thermal and mass diffusion. The effects of various parameters on mean velocity and mean skin-friction are shown graphically followed by a comparative study of Newtonian and non-Newtonian (visco-elastic). rarefied states.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00653647
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  • 4
    Electronic Resource
    Electronic Resource
    Thermal and mass diffusion on MHD natural convective flow of a rarefied gas along vertical porous plate (1984)
    Springer
    Astrophysics and space science 98 (1984), S. 81-99 
    Details
    ISSN: 1572-946X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The flow of an electrically conducting incompressible rarefied gas due to the combined buoyancy effects of thermal and mass diffusion past an infinite vertical porous plate with constant suction has been studied in the presence of uniform transverse magnetic field. The problem has been solved for velocity, temperature, and concentration fields. It has been observed that mean velocity and the mean temperature are affected by the Grashof numbersG 1 andG 2, the slip parameterh 1, temperature jump coefficienth 2, concentration jump coefficienth 3 and magnetic field parameterM. The amplitude and the phase of skin-friction and the rate of heat transfer are affected by frequency in addition to the above parameters. They are shown graphically. The numerical values of the mean skin-friction and the mean rate of heat transfer are also tabulated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00651952
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  • 5
    Electronic Resource
    Electronic Resource
    Evolutionary synthesis of separation processes (1981)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 27 (1981), S. 578-587 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: This paper deals with the problem of finding, among many alternatives, the sequence of separation units that will isolate desired products from given feed at the minimum cost. Multicomponent products can be specified. An evolutionary procedure is presented. This method consists of two phases. In the first phase, a good initial structure is created by heuristic methods. In the second phase, the initial structure is successively modified by making evolutionary structural changes. This logic has been programmed on a digital computer and has been tested on several problems.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690270407
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    Paper (German National Licenses)
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