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Studies on the mechanism of reduction in glomerular filtration rate after benzolamide (1980)

Tucker, Bryan J. ; Blantz, Roland C.

Springer

Pflügers Archiv 388 (1980), S. 211-216

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ISSN: 1432-2013

Keywords: Glomerular filtration rate ; Reninangiotensin system

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract In previous studies, we have shown that benzolamide, a carbonic anhydrase inhibitor with diuretic activity confined primarily to the proximal tubule, causes a significant reduction in nephron filtration rate by increasing afferent and efferent arteriolar vascular resistance [30], possibly through an activation of tubuloglomerular feedback mechanism. The present studies were designed to determine if infusion of 1-sar, 8-ala angiotensin II, an angiotensin II receptor antagonist (AIIA) could prevent and reverse the vasoconstriction and resulting reduction in SNGFR with benzolamide. Benzolamide administration to hydropenic rats decreased SNGFR by 5.0±1.3 nl/min and AIIA infusion in these rats completely restored SNGFR to the control, prebenzolamide values. These results occurred when SNGFR was measured in both proximal and distal tubules. In another group of hydropenic rats prior AIIA infusion completely prevented any alteration in SNGFR with benzolamide administration (33.0±2.8 vs. 32.3±1.5 nl/min). Benzolamide administration did increase the late proximal tubular flow rate during AIIA infusion (17.2±1.1 to 23.4±1.1 nl/min,P〈0.01), demonstrating that AIIA did not act by preventing the diuretic action of benzolamide in the proximal tubule. AIIA infusion alone did not alter control SNGFR or nephron plasma flow, suggesting that the effect of AIIA was not that of a non-specific vasodilator. These studies suggest that the renal vasoconstriction and reduction in SNGFR which results from benzolamide administration is mediated by the local action of angiotensin II.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00658483

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The mechanism for enhanced autoadhesion in azoester-modified polybutadienes (1984)

Roland, C. M. ; Böhm, G. G. A.

New York, NY [u.a.] : Wiley-Blackwell

Journal of Applied Polymer Science 29 (1984), S. 3803-3812

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ISSN: 0021-8995

Keywords: Chemistry ; Polymer and Materials Science

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics

Notes: The addition of IAD pendant groups to PB molecules results in a larger effective chain crosssectional area with consequent decrease in chain entanglements. This causes the rubber to be more complaint at low strains and strain rates. Simultaneously, the IAD structures give rise to polar and H-bond interactions which cause the material to exhibit strong adhesion and to possess high green strength. As a result, the IAD-PB is a relatively rare example of a synthetic polymer with good autoadhesive properties.

Additional Material: 7 Ill.