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  • 1
    Electronic Resource
    Electronic Resource
    Pancreatic PP cell distribution and hyperplasia (1980)
    Springer
    Virchows Archiv 387 (1980), S. 319-331 
    Details
    ISSN: 1432-2307
    Keywords: Endocrine pancreas ; PP cells ; Immunocytochemistry ; Distribution ; Normal pancreas ; Chronic pancreatitis ; Pancreatic carcinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The endocrine pancreatic tissue from 13 patients with severe chronic pancreatitis, 5 patients with pancreatic duct carcinoma and 4 non-diseased pancreases was analysed by immunocytochemistry and morphometry. The controls revealed two distinct islet types with different regional distribution. The lower dorsal part of the pancreatic head contained islets with irregular outlines and a high number of PP cells (PP-cells 60.4±4.1%; B-cells 29.4±4.6%; A-cells 7.4±1.5%; D-cells 2.8±0.6%). The other parts of the pancreas contained compact islets with only a few PP cells (PP-cells 1.0±0.4%; B-cells 69.3±3.0%; A-cells 24.1±2.1%; D-cells 5.8±0.5%). In chronic pancreatitis the sclerotic tissue of the body and the tail region contained compact islets with altered cell inter-relationships when compared with controls. While the number of B-cells was diminished (48.5%), A and PP cells appeared to be increased in number (42.7 and 4.1%, respectively). Furthermore, ductulo-insular proliferations were conspicuous (nesidioblastosis) with budding-off of small endocrine cell clusters made up predominantly of A and PP cells. In 3 patients with pancreatic carcinoma increased numbers of PP cells and of A cells were found along the advancing edge of the carcinoma. The data emphasize the necessity of taking into consideration regional PP cell distribution in each case in which an increase of PP cells is observed. True hyperplasia is found in chronic pancreatitis and, focally, in some cases with pancreatic carcinoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00454835
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  • 2
    Electronic Resource
    Electronic Resource
    Die tumorhemmende Wirkung von Cholestyramin in der Hepatocarcinogenese (1981)
    Springer
    Langenbeck's archives of surgery 354 (1981), S. 19-29 
    Details
    ISSN: 1435-2451
    Keywords: Bile acids ; Diethylnitrosamine ; Hepatocarcinogenesis ; Cholestyramine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Der Einfluß von Cholestyramin in der Hepatocarcinogenese wurde an Wistar—Ratten untersucht. Nach 14wöchentlicher intragastraler Applikation von 50 mg Diäthylnitrosamin/kg entwickelten bei simultaner Verabreichung von 1,3 % Cholestyraminzusatz im Futter die Hälfte der Versuchstiere Lebertumoren. Dagegen kam es unter ähnlichen experimentellen Bedingungen, aber ohne Cholestyramin im Futter bei fast allen Tieren der Kontrollgruppe zu Tumorentstehung. Die Sequestration von Gallensäuren und die verminderte Bildung der toxischen Lithocholsäure konnte als Erklärung herangezogen werden, warum im Experiment die Induktion von Lebercarcinom durch Diäthylnitrosamin reduziert wird.
    Notes: Summary The influence of cholestyramine on hepatocarcinogenesis was investigated in the Wistar rat. After 14 weekly gastric instillation of 50 mg diethylnitrosamine/kg and simultaneous administration of diet supplement with 1.3 % cholestyramine, half of the animals developed hepatic tumors. In contrast, nearly all the animals in the control group under similar experimental conditions, but without the cholestyramine supplement in their diet, developed hepatic tumors. The sequestration of bile acids and the reduction of the noxious lithocholic acid could be considered as an explanation for the modification of hepatic tumors induced by diethylnitrosamine in the Wistar rat.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01834013
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    Paper (German National Licenses)
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