ISSN:
1432-2072
Keywords:
Apomorphine
;
Hypothermia
;
Antidepressants
;
Neuroleptics
;
Screening
;
Stereotypy
;
Verticalization
;
Mice
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The antagonism of hypothermia induced by two doses of apomorphine (1 or 16 mg/kg) is proposed as an improved screening test for both neuroleptics and antidepressants. Low dose apomorphine-induced hypothermia (1 mg/kg) differentiates sulpiride-like neuroleptics (which better antagonize this effect of apomorphine than other effects such as stereotyped behavior) from haloperidol-like drugs. The latter equally antagonize the two effects of apomorphine. The effects of sulpiride are also distinct from those of chlorpromazine-like drugs which strongly antagonize stereotyped behavior, but not hypothermia induced by apomorphine. Hypothermia induced by a high dose of apomorphine (16 mg/kg) is not antagonized by neuroleptics, but is strongly antagonized by antidepressants (imipramine-like drugs, amineptine, amoxapine, nomifensine, viloxazine) and potential antidepressants (beta-adrenergic stimulants). The use of these two tests rapidly screens both antidepressants and neuroleptics and classifies neuroleptics according to their profile of action on the dopaminergic system.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00433508
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