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  • 1
    Electronic Resource
    Electronic Resource
    Effect of 5,7-dihydroxytryptamine on serotonergic control of prolactin secretion and behavior in rats (1981)
    Springer
    Psychopharmacology 73 (1981), S. 188-193 
    Details
    ISSN: 1432-2072
    Keywords: 5,7-Dihydroxytryptamine ; Prolactin ; Supersensitivity ; Serotonin ; 5-HTP ; Operant responding ; Myoclonic syndrome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The intracisternal administration of 5,7-dihydroxytryptamine (5,7-DHT) to rats resulted in a potentiated response to 5-hydroxytryptophan (5-HTP) when the animals were tested 30 days later. The 5-HTP-induced changes include elevation of serum prolactin decrease in operant responding, and the magnitude of the “serotonin behavioral syndrome” observed after 5-HTP administration. The serotonin concentration in brains of 5,7-DHT-treated animals reached maximum earlier and remained elevated longer than that of controls following administration of 5-HTP. Brain norepinephrine and dopamine concentration were not affected by 5-HTP in either group of animals. The increase in serum prolactin concentration elicited by administration of the serotonergic agonists quipazine or 5-methyxy-N,N-dimethyltryptamine and by the serotonin uptake inhibitor fenfluramine also was potentiated by pretreating rats with 5,7-DHT. These data suggest that both serotonergic receptor supersensitivity and the absence of presynaptic uptake sites contribute to the enhanced responses to 5-HTP occurring in rats previously treated with 5,7-DHT. The findings further demonstrate that both behavioral and hormonal measures can be used to assess the sensitivity of serotonergic receptors and indicate that 5,7-DHT may be useful in evaluating the role of serotonergic neurons in neuroendocrine function.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00429216
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  • 2
    Electronic Resource
    Electronic Resource
    Behavioral effects of 5-methoxy-N,N-dimethyltryptamine and dose-dependent antagonism by BC-105 (1983)
    Springer
    Psychopharmacology 80 (1983), S. 156-160 
    Details
    ISSN: 1432-2072
    Keywords: 5-OMeDMT ; Discriminative stimulus ; LSD ; Hallucinogens ; BC-105 ; Operant responding ; Serotonin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The discriminative effects of 5-methoxy-N,N-dimethyltryptamine (5-OMeDMT) were studied in rats trained to discriminate 1.5 mg/kg or 3.0 mg/kg 5-OMeDMT from saline. A series of antagonist and generalization tests revealed that (1) antagonism of the 5-OMeDMT stimulus response by the presumed serotonin antagonist BC-105 depended on the dose of 5-OMeDMT, (2) the 5-OMe DMT stimulus generalized to LSD, and (3) like 5-OMeDMT, antagonism of the LSD generalization response by BC-105 depended on the dose of LSD. In a second study, with rats responding under a variable-interval (VI) 15-s schedule of reinforcement, doses of 1.0–3.0 mg/kg 5-OMeDMT significantly decreased response rate. Furthermore, the decrease in responding produced by the administration of 1.5 mg/kg (but not by 3.0 mg/kg) 5-OMeDMT was blocked by BC-105. This dosedependent antagonism was of particular interest since the 1.5 mg/kg and 3.0 mg/kg dose of 5-O-MeDMT had essentially the same effect on responding when given alone. The results of both studies emphasize the importance of 5-OMeDMT dose in antagonism experiments.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00427960
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  • 3
    Electronic Resource
    Electronic Resource
    An evaluation of the selectivity of fenmetozole (DH-524) reversal of ethanol-induced changes in central nervous system function (1980)
    Springer
    Psychopharmacology 69 (1980), S. 149-155 
    Details
    ISSN: 1432-2072
    Keywords: Fenmetozole ; Ethanol ; Aerial righting reflex ; Conflict behavior ; Guanosine 3′,5′-monophosphate ; Physical dependence ; Physiological antagonism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The selectivity and specificity of fenmetozole (DH-524) [2(3,4-dichlorophenoxy-methy))2-imidazole HCl] as an antagonist of the actions of ethanol were examined. Fenmetozole (15–30 g/kg) reduced ethanol-induced impairment of the aerial righting reflex without changing blood or brain ethanol content, indicating that the antagonistic actions of fenmetozole were not due to change in the pharmacokinetics of ethanol. Since fenmetozole also reduced aerial righting reflex impairment due to phenobarbital, chlordiazepoxide, and halothane, this action of fenmetozole was not specific to ethanol. In mice, both the ethanolinduced increase in locomotor activity at 2.0 g/kg and the decrease caused by 4.0 g/kg were antagonized by fenmetozole. In addition, fenmetozole attenuated the ethanol-induced reduction in cerebellar cyclic guanosine monophosphate (cGMP) content, but the drug also significantly elevated cGMP levels in this tissue when given alone. Fenmetozole did not alter ethanolinduced increases in punished drinking in a conflict test, except at a high dose which alone decreased both punished and unpunished responding. Fenmetozole also failed to precipitate ethanol withdrawal-like reactions when given to physically-dependent, intoxicated rats. Thus, the antagonistic action of fenmetozole against ethanol would not seem to be related to a specific receptor interaction but rather may be the result of a physiological antagonism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00427641
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  • 4
    Electronic Resource
    Electronic Resource
    13C-NMR sequence analysis of polyesters from pentaerythritol and caprolactone (1981)
    New York : Wiley-Blackwell
    Journal of Polymer Science: Polymer Chemistry Edition 19 (1981), S. 1329-1336 
    Details
    ISSN: 0360-6376
    Keywords: Physics ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Reaction of pentaerythritol (1) or dipentaerythritol with caprolactone yields prepolymers of the general structure \documentclass{article}\pagestyle{empty}\begin{document}$$ {\rm C} { \left( {\rm CH}_2 {\rm OH} \right)_4 } \hbox{--} {\rm i} \left [ {\rm CH}_2 {\rm O} \left( {\rm COCH}_2 {\rm CH}_2 {\rm CH}_2 {\rm CH}_2 {\rm CH}_2 {\rm O} \right)_{\rm n} {\rm H} \right]_{\rm i}$$\end{document} for i = 1, 2, 3, and 4 (2)-(5). The 13C chemical shifts of the quaternary carbons in (1)-(5) differ by more than 0.5 ppm. Conditions were determined to obtain quantitative intensity ratios of these carbons. The relative intensities give the distribution of the various branched structures and permit calculations of the average number of caprolactones per branch. Results are reported for caprolactone/polyol mole ratics of 3-66.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pol.1981.170190605
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  • 5
    Electronic Resource
    Electronic Resource
    Sequence distribution in polyethylene/tetramethylene terephthalate copolyesters by 13C-NMR (1980)
    New York : Wiley-Blackwell
    Journal of Polymer Science: Polymer Chemistry Edition 18 (1980), S. 559-563 
    Details
    ISSN: 0360-6376
    Keywords: Physics ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: 13C-NMR gives sequence information in copolyesters synthesized from ethylene glycol (EG), 1,4-butane diol (BD), and methyl terephthalate (TP). The EG-TP-EG and BD-TP-BD blocks are distinguishable from the unsymmetrical diester sequence EG-TP-BD. The carbonyl and aromatic quaternary carbons of terephthalate have different chemical shifts but identical relaxation times and nuclear Overhauser enhancements in the three different triad sequences. Peak areas indicate random copolymerization of the three copolyesters studied.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pol.1980.170180216
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  • 6
    Electronic Resource
    Electronic Resource
    N-methyl-substituted aromatic polyamidesPaper presented in part at the 28th Southeastern Regional Meeting of the American Chemical Society, Gatlinburg, Tennessee, October 1976. (1980)
    New York : Wiley-Blackwell
    Journal of Polymer Science: Polymer Chemistry Edition 18 (1980), S. 1047-1059 
    Details
    ISSN: 0360-6376
    Keywords: Physics ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A series of N-methyl-substituted aromatic polyamides derived from the secondary aromatic diamines 4,4′-bis(methylamino)diphenylmethane, 3,3′-bis(methylamino)diphenylmethane, 4,4′-bis(methylamino)benzophenone or 3,3′-bis(methylamino)benzophenone and isophthaloyl dichloride, and terephthaloyl dichloride or 3,3′-diphenylmethane dicarboxylic acid dichloride was prepared by high-temperature solution polymerization in s-tetrachloroethane. Compared with analogous unsubstituted and partly N-methylated aromatic polyamides, the full N-methylated polyamides exhibited significantly lower glass transition temperatures (Tg), reduced crystallinity, improved thermal stability, and good solubility in chlorinated solvents.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pol.1980.170180323
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  • 7
    Electronic Resource
    Electronic Resource
    Line broadening in the 13C NMR spectra of bulk polymers above Tg (1983)
    New York : Wiley-Blackwell
    Journal of Polymer Science: Polymer Physics Edition 21 (1983), S. 2551-2559 
    Details
    ISSN: 0098-1273
    Keywords: Physics ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: The effects of magic-angle sample spinning (MAS), high-power decoupling, and resonance frequency on the 13C NMR linewidths of bulk polyisobutylene and bulk trans-polybutadiene are examined. The 13C linewidths increase with resonance frequency, are unaffected by high-power decoupling, and are reduced to different extents by MAS. The dominant contribution of the natural linewidth of the polyisobutylene lines is confirmed. The two carbons of trans-polybutadiene have approximately equal linewidths under all conditions, a result that eliminates residual chemical shift anisotropy as a major contributor to the linewidths. The large reduction of the trans-polybutadiene linewidths with MAS, coupled with the above result, suggests that microscopic variation of magnetic susceptibility is the major factor for this semicrystalline polymer. Cross-polarized 13C spectra of trans-polybutadiene were obtained with and without MAS. With MAS, resonances due to the crystalline and amorphous components were resolved. The principal components of the chemical shift tensor of the vinylene carbons were obtained from the spectrum without MAS.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pol.1983.180211211
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  • 8
    Electronic Resource
    Electronic Resource
    Carbon-13 NMR microstructural characterization of dichlorocarbene adducts of polybutadiene (1983)
    New York : Wiley-Blackwell
    Journal of Polymer Science: Polymer Chemistry Edition 21 (1983), S. 89-96 
    Details
    ISSN: 0360-6376
    Keywords: Physics ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: 13C-NMR has been used to examine a number of dichlorocarbene adducts of cis- and trans-polybutadiene prepared in a two-phase system. Dichlorocarbene was generated by reaction of aqueous or solid NaOH or KOH with CHCl3 in the presence of a phase transfer catalyst. Monomer compositions, comonomer sequence lengths, and stereochemical information were obtained for the resulting polymers. The polymers examined here were stereochemically pure and were treated as simple copolymers. Samples prepared using aqueous NaOH can be described as essentially random copolymers over the entire range of monomer composition. Samples prepared using solid alkali-metal hydroxides contain a higher fraction of blocked units than a polymer of comparable composition prepared using aqueous NaOH. This blockiness can coincide with the presence of two glass transition temperatures and a two-phase morphology as seen by transmission electron microscopy. Fractionation of a substantially blocked sample yielded a chlorine-poor fraction which was a random copolymer and a chlorine-rich fraction which was more blocked than the original unfractionated material.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pol.1983.170210110
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