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  • 1980-1984  (2)
  • GABA receptors  (1)
  • Neuromuscular  (1)
Material
Years
  • 1980-1984  (2)
Year
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Experimental brain research 38 (1980), S. 109-114 
    ISSN: 1432-1106
    Keywords: Neuromuscular ; Reflexes ; Gait
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary If an obstacle impedes the forward swing of a cat's foot, the animal responds by rapidly lifting the foot over the obstacle. In freely moving cats, the electrical activity of hindlimb flexors and extensors was recorded during such reactions elicited both mechanically and electrically. The sequencing of muscle activity was more complex and longer in duration in the mechanically elicited reactions. Anaesthesia of the foot dorsum abolished responses in ankle extensors and knee flexors, and converted the responses of ankle flexors to simple stretch reflexes. Although our findings closely resemble those reported for chronic spinal kittens, there are interesting points of difference, which should be taken into account if the notion of a purely spinal mediation of the placing reaction during stepping is to be accepted.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 317 (1981), S. 54-60 
    ISSN: 1432-1912
    Keywords: Substantia nigra ; GABA receptors ; Stereotypy ; Rotational behaviour ; Motor disturbances
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The behaviour of cats after unilateral injections of muscimol, picrotoxin and bicuculline into the posterior and lateral parts of the substantia nigra was observed. The antagonism between muscimol and picrotoxin was limited to some effects of the drugs: (1) muscimol-induced sniffing, licking and enhanced locomotor activity was attenuated by picrotoxin in contrast to the muscimol-induced contralateral turning which was even enhanced by picrotoxin; (2) picrotoxin-induced balance disorders as well as characteristic motor disturbances in the hind legs remained unaffected following an additional treatment with muscimol. Furthermore, subcutaneously given apomorphine did not affect the picrotoxin-induced balance and hind leg disorders, although the apomorphine-induced stereotyped behaviour itself was enhanced and suppressed by intranigral administration of muscimol and picrotoxin respectively. The conclusion is reached that there are at least two distinct populations of GABA receptors within the substantia nigra: one group controlling or being controlled by dopaminergic neurons and one group operating fully independently of the former neurons. The similarities to experiments on rats are stressed. The mechanism underlying the muscimol-resistant picrotoxin-induced effects (balance disorders and motor disturbance of the hind legs) is discussed.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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