ISSN:
1573-1111
Schlagwort(e):
Cyclodextrin
;
Self-Diffusion
;
Nuclear Magnetic Resonance
;
Inclusion-Complex
;
Hydrophobic Interaction
;
Alcohols
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Chemie und Pharmazie
Notizen:
Abstract It is demonstrated that substrate binding to α- and β-cyclodextrins (CD) in solution can conveniently and directly be monitored from multicomponent self-diffusion data on these solutions, using the Fourier Transform NMR pulsed-gradient spin-echo technique. Included are aromatics and a series of alcohols ranging from methanol to octanol. Experimentally it was found thatn-alcohols associate more strongly with α-CD than with β-CD. As the bulkiness of the alcohol increased, binding to β-CD was enhanced while the reverse effect was observed in the case of α-CD. For both cyclodextrins it was found thatn-alcohol complexation in the homologous series was attributable to an increment in standard free energy of complexation of ∼ −3.0 kJ/mol for each −CH2− group, suggesting that the binding mechanism is of a hydrophobic nature.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF00656818
Permalink
