ISSN:
1432-1238
Keywords:
Glucocorticoid
;
Adult respiratory distress syndrome
;
Posttraumatic pulmonary insufficiency
;
Lung water
;
Monocrotaline
;
Pulmonary circulation
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Methylprednisolone, 30 mg/kg body weight, was given to dogs 30 min and 4 h after injection of monocrotaline to produce noncardiogenic pulmonary edema. Control animals received monocrotaline but not corticosteroids. After 6 h the steroid-treated animals demonstrated significantly better gas exchange and significantly less pulmonary edema. A possible mechanism of this beneficial effect of steroids is inhibition of complement-leukocyte interactions which may mediate pulmonary microvascular injury. The results lend some support to the clinical practice of short-term pharmacologic doses of steroids in noncardiogenic pulmonary edema.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01738614
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