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  • 1980-1984  (2)
  • Neuromuscular  (1)
  • fusimotoneurons  (1)
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  • 1980-1984  (2)
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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Experimental brain research 38 (1980), S. 109-114 
    ISSN: 1432-1106
    Keywords: Neuromuscular ; Reflexes ; Gait
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary If an obstacle impedes the forward swing of a cat's foot, the animal responds by rapidly lifting the foot over the obstacle. In freely moving cats, the electrical activity of hindlimb flexors and extensors was recorded during such reactions elicited both mechanically and electrically. The sequencing of muscle activity was more complex and longer in duration in the mechanically elicited reactions. Anaesthesia of the foot dorsum abolished responses in ankle extensors and knee flexors, and converted the responses of ankle flexors to simple stretch reflexes. Although our findings closely resemble those reported for chronic spinal kittens, there are interesting points of difference, which should be taken into account if the notion of a purely spinal mediation of the placing reaction during stepping is to be accepted.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-2013
    Keywords: muscle spindles ; fusimotoneurons ; substantia nigra ; picrotoxin ; muscimol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Picrotoxin and muscimol were unilaterally injected into the postero-lateral part of the reticular zone of substantia nigra (p1SNR) through chronically implanted guide cannulae in ketamine-anasthetized cats. Afferent activity of pretibial flexor muscle spindle primary and secondary endings was recorded before and after drug administration, and spindle sensitivity monitored during both sinusoidal and ramp stretch of the receptor-bearing muscle. From changes in spindle sensitivity after drug injection it is deduced that unilateral block by picrotoxin of the action of GABA on postsynaptic receptors in plSNR removes tonic static fusimotor action from flexor muscle spindle primary endings. Secondary endings seemed largely unaffected. The effect on primary endings is reversed by a subsequent injection of muscimol. It is concluded that the central nervous system, through GABA-modulated nigral output neurons, can control static fusimotor action onto flexor muscle spindle primary and secondary endings separately to some extent.
    Type of Medium: Electronic Resource
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