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  • 1980-1984  (2)
  • Nonionic surfactants with even and odd carton atoms  (1)
  • blood pressure  (1)
  • dopamine-beta-hydroxylase  (1)
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Year
Keywords
  • 1
    Electronic Resource
    Electronic Resource
    Antihypertensive effect of E-643, a new alpha-adrenergic blocking agent (1981)
    Springer
    European journal of clinical pharmacology 20 (1981), S. 399-405 
    Details
    ISSN: 1432-1041
    Keywords: alpha-adrenergic blocker ; hypertension ; blood pressure ; pulse rate ; noradrenaline ; plasma renin activity ; plasma aldosterone ; dopamine-beta-hydroxylase ; E-643
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary To determine whether E-643, a new α-blocking agent, would reduce the blood pressure, regardless of the posture, a 1 mg dose was given 3 times daily for 7 consecutive days, to 8 male and 7 female inpatients, aged 37–73 years, with essential hypertension. Blood pressure and pulse rate were measured daily in the supine, sitting and standing positions. Before and after the treatment with E-643, plasma levels of noradrenaline, adrenaline, dopamine-β-hydroxylase, renin and aldosterone were determined, samples being obtained with the subjects recumbent and after standing upright for 60 min. A significant reduction in the systolic and diastolic blood pressures was evident in the supine (172±31/100±12 → 151±28/89±14 mmHg), sitting (158±22/101±11 → 138±28/89±15 mmHg) and standing (153±32/103±21 → 129±31/89±20 mmHg) positions. The reduction in blood pressure remained unchanged throughout the period of administration of E-643. Pulse rate was not affected when the subjects were supine (67±10 → 69±10 beats/min), but was increased in the sitting (68±10 → 73±9 beats/min) and standing (73±10 → 81±11 beats/min) positions. The increased pulse rate tended to decline during continued administration of E-643. Treatment with E-643 produced no significant change in plasma levels of adrenaline, noradrenaline, dopamine-β-hydroxylase, renin and aldosterone. The antihypertensive effect of treatment was more prominent in the patients with higher levels of plasma catecholamines and dopamine-β-hydroxylase, and was less prominent in those with higher plasma renin and aldosterone. Two patients had temporary bouts of dizziness and visual disturbances, but there were no subjective complaints during treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00542090
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Effects of alkyl chain length on surface and micellar properties of octaethyleneglycol-n alkyl ethers (1981)
    Springer
    Colloid & polymer science 259 (1981), S. 761-766 
    Details
    ISSN: 1435-1536
    Keywords: Nonionic surfactants with even and odd carton atoms ; contribution of two moieties
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Summary Surface and micellar properties of a homologous series of Octaethylene glycol-n-alkyl ethers (C n E8;n = 9 to 15) have been studied in aqueous solutions by the surface tension measurements. The effects of the alkyl chain length comprising even and carbon numbers have been examined in order to evaluate the surface free energy ΔG A-W and the standard free energy ΔG m for the micellization obtained from their surface tension data. The areas per molecule and the equilibrium surface tension values at the CMC decreased with an increasing carbon number and they showed zigzag curves by the difference in even and odd carbon numbers. These findings may be attributed to the differences in the molecular orientation between the molecules with even carbon number and ones with odd carbon number on the air-water interface at CMC. ΔG A-W values decreased linearly with an increasing alkyl chain length but did not show a zigzag line by the differences in even and odd carbon numbers. This suggests that the molecular orientation is not influenced by the difference between their even and odd carbon numbers in the alkyl chain on the surface of the very diluted solution, and their molecules form some stable adsorbed films with an increase of the alkyl chain length. A division of ΔG A-W into the contribution made both by the hydrophilic group ΔG A-W (-W) and by the hydrophobic group ΔG A-W (-CH2-) was attempted as follows; ΔG A-W (-CH2-) = − 0.80 kcal/mol and ΔG a-W (-W) = + 0.15 kcal/mol. The free energy changes ΔG m of micellization were discussed on the basis of the CMC data obtained from the surface tension measurements by treating the formation of micelles as analogous to phase separation, and the contribution from the each moieties in the molecule were calculated as follows; ΔG m (-CH2-) = − 0.68 kcal/mol and ΔG m (-W) = + 1.54 kcal/mol. The difference between ΔG A-W and ΔG m is discussed using their data.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01419322
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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