ZIB

Hits per page

hits 1 - 2 | 2 hits

Sorting

Electronic Resource

Pharmacokinetics of meptazinol after single and multiple oral administration to elderly patients (1984)

Norbury, H. M. ; Franklin, R. A. ; Graham, D. F. ; [et al.]

Springer

European journal of clinical pharmacology 27 (1984), S. 223-226

add to mindlist on the mindlist

Details

ISSN: 1432-1041

Keywords: meptazinol ; pharmacokinetics ; multiple dosing ; elderly patients

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology , Medicine

Notes: Summary Oral administration of meptazinol (200 mg Meptid®) to male and female geriatric patients (〉70 years) resulted in rapid absorption, with peak drug concentrations at 0.5 to 3 h after dosage. Subsequent elimination also proceeded rapidly with a half-life of 3.39 h (±0.26 SEM) after a single dose and 4.97 h (±0.80 SEM) after 13 consecutive 6-h doses. These values were not statistically different. There was no accumulation of meptazinol above that expected from the single-dose kinetics. Plasma protein binding of meptazinol was 33.8% (±0.74 SEM). No sex difference was apparent in any of the pharmacokinetic parameters determined. Comparison of these results with those obtained in an earlier study in young volunteers showed that although the half-life of meptazinol was somewhat longer than the value of 2 h seen in the young, peak plasma concentrations after single and multiple dosing were similar for both age groups, implying that clearance remained largely unaltered. It was concluded that there was no pharmacokinetic basis for recommending a reduction in dosage when treating elderly patients with oral meptazinol.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00544049

Permalink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

Electronic Resource

Kinetics and mechanism of the oxidation of n-acetyl l-cysteine by 2,6-dichloroindophenol in methanol-water medium (1982)

Shrivastava, Manjul ; Mishra, K. K. ; Sinha, B. P.

New York, NY : Wiley-Blackwell

International Journal of Chemical Kinetics 14 (1982), S. 451-456

add to mindlist on the mindlist

Details

ISSN: 0538-8066

Keywords: Chemistry ; Physical Chemistry

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology

Notes: The principal reactants interact in a molar ratio of 2:1 forming dihydroindophenol and the corresponding disulfide. The order of reaction is unity with respect to each reactant, namely, N-acetyl L-cysteine and indophenol. The rate shows an inverse linear relation with hydroxyl ions. It is not influenced by the variation in the initial concentration of indophenol. The rate increases on adding the salts possessing a cholinergic effect and the neutral electrolytes, as well as on increasing the dielectric constant of the medium. The products, namely, N-acetyl L-cystine (disulfide) and the leuco dye, do not influence the rate. A low energy and a highly negative entropy of activation (4.11 kcal/mol and -60.49 e.u., respectively) suggest the formation of an outer sphere complex as the rate-determining step.

Additional Material: 2 Ill.