ISSN:
1432-069X
Keywords:
Toxic epidermal necrolysis
;
Lymphopenia
;
T-Lymphocyte subsets
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary A lymphopenia (peripheral-blood-lymphocyte count 〈1,000/mm3) was observed in seven out of ten patients with toxic epidermal necrolysis (TEN). The enumeration of T-lymphocyte subsets with monoclonal antibodies showed a decreased number of pan T-lymphocytes (OKT3-positive), which was related to a profound depletion of OKT4-positive cells. In contrast, OKT8-positive cell counts were not significantly changed. This abnormal balance of T-lymphocytes was linked to the acute phase of the disease and was not found after recovery. The pathogenetic mechanisms of such T-lymphocyte abnormalities in TEN remain unclear.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00406477
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