ISSN:
1432-1335
Keywords:
ODC
;
Phorbol ester
;
Tumor promoter
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Measurements were made of induction of ornithine decarboxylase activity after painting mouse skin with 12-O-hexadecanoyl-16-hydroxyphorbol-13-acetate and its two epimeric 4-deoxy-analogs, 12-O-hexadecanoyl-4-deoxy-16-hydroxyphorbol-13-acetate and 12-O-hexadecanoyl-4-deoxy-4α-16-hydroxyphorbol-13-acetate. The inductive activities of HHPA and 4-deoxy-HHPA were similar, but 4-deoxy-4α-HHPA had no inductive activity. These findings on natural phorbol esters confirm that both the 4β-hydrogen and the 4β-hydroxyl in phorbol esters are essential for ODC-inducing activity. The interactions of 4-deoxy-HHPA and 4-deoxy-4α-HHPA with a possible receptor are discussed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00413172
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