ZIB

Treffer pro Seite

Treffer 1 - 1 | 1 Treffer

Sortierung

Digitale Medien

The influence of protein binding on disopyramide clearance (1982)

Bryson, S. M. ; Lawrence, J. R. ; Steele, W. H. ; [weitere]

Springer

European journal of clinical pharmacology 23 (1982), S. 453-456

zur Merkliste hinzufügen auf der Merkliste

Details

ISSN: 1432-1041

Schlagwort(e): disopyramide ; steady state ; clearance ; plasma protein binding

Quelle: Springer Online Journal Archives 1860-2000

Thema: Chemie und Pharmazie , Medizin

Notizen: Summary Individual disopyramide clearance is not constant and previous studies have suggested that this may be time and/or concentration dependent. Steady state disopyramide concentrations were achieved in six volunteer subjects at each of three infusion rates. Drug analysis was by HPLC and protein binding was determined by ultrafiltration. The disopyramide free fraction was concentration dependent and marked interindividual variability was observed. Disopyramide clearance was independent of time but dependent on total plasma concentration. This can be completely explained by non-linear protein binding since free disopyramide clearance was observed to be independent of free concentration.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00605997

Permalink

Bibliothek	Standort	Signatur	Band/Heft/Jahr	Verfügbarkeit

Andere fanden auch interessant ...

Artikel (Nationallizenzen)

Volltext

Treffer 1 - 1 | 1 Treffer