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  • 1
    Electronic Resource
    Electronic Resource
    Are the binding and degradation of low density lipoprotein altered in type 2 (non-insulin-dependent) diabetes mellitus? (1982)
    Springer
    Diabetologia 23 (1982), S. 28-33 
    Details
    ISSN: 1432-0428
    Keywords: Type 2 diabetes mellitus ; low density lipoprotein ; lipoprotein binding ; lipoprotein degradation ; fibroblast, macrophage
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Studies in vitro have shown that glycosylation of low density lipoprotein (LDL) will decrease its ability to bind to its receptor. We have evaluated the possibility that such an event might occur in vivo in diabetes by comparing the binding and degradation by normal fibroblasts and mouse peritoneal macrophages of LDL obtained from normal control subjects and patients with Type 2 (non-insulin-dependent) diabetes mellitus. When compared with control subjects, Type 2 diabetic patients had elevated fasting glucose (increased by 160%), haemoglobin A1c (increased by 75%), triglyceride (increased by 550%), and cholesterol (increased by 48%) levels. LDL from Type 2 diabetic patients displayed populations of particles with more heterogeneous hydrated densities than LDL from control subjects, with enrichment in the triglyceride content of the lighter population. 125I-LDL from normal and Type 2 diabetic subjects bound to fibroblasts with similar binding affinities and binding capacities. The kinetics of degradation of LDL from normal and Type 2 diabetic subjects by fibroblasts were also similar. Furthermore, all populations of LDL particles from Type 2 diabetic patients were bound and degraded by normal fibroblasts in identical fashions. In addition, 125I-LDL from normal and Type 2 diabetic subjects were not bound or degraded by mouse peritoneal macrophages. It is concluded that the LDL of patients with Type 2 diabetes with moderate hyperglycaemia are not modified sufficiently to alter their normal binding and degradation by human fibroblasts or to cause their uptake by mouse peritoneal macrophages.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00257726
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    High-temperature oxidation of Ti-4.32 wt.% Nb alloy (1980)
    Springer
    Oxidation of metals 14 (1980), S. 147-165 
    Details
    ISSN: 1573-4889
    Keywords: oxidation in air or oxygen ; kinetics ; oxide identification ; oxygen diffusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The oxidation kinetics of Ti-4.32 wt.% Nb (2.27 at.%) alloy in either air or oxygen under 1 bar pressure have been investigated in the temperature range of 1255–1471 K. For oxidation in oxygen the kinetics follow consecutively decreasing parabolic rate laws. The kinetics become nonparabolic after prolonged oxidation in air. X-ray data reveal the presence of TiO2 (rutile) as the main oxide. The presence of Ti2O, δ-TiN, and ɛ-TiN is found on the metal surface after oxidation in air. Microhardness and electron microprobe measurements are used to determine Ti, Nb, O, and N profiles across the oxidized alloy. The oxygen diffusion coefficient in the alloy can be expressed byD=65.6 exp(−234.3/RT) with the activation energy in kilojoules per mole. The oxidation behavior of the alloy is explained.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00603991
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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