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  • 1
    Electronic Resource
    Electronic Resource
    Esthesioneuroblastoma: Ultrastructural, immunohistological and biochemical investigation of one case (1984)
    Springer
    European archives of oto-rhino-laryngology and head & neck 239 (1984), S. 133-144 
    Details
    ISSN: 1434-4726
    Keywords: Esthesioneuroblastoma ; Intermediate filaments ; Secretory granules ; Ultrastructure ; Immunohistology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A case of esthesioneuroblastoma, the pathological diagnosis of which almost always causes great difficulties, was investigated ultrastructurally, biochemically, and immunohistologically, using antibodies against the five known types of intermediate filaments [keratin, vimentin, desmin, glial fibrillary acidic protein (GFAP) and neurofilaments]. The tumour cells did not react with antibodies against any of the five intermediate filament proteins. Ultrastructural investigations showed dense cored secretory granules in the cytoplasm and cell processes. Thus, immunohistology offers by “exclusion” a differential diagnosis to avoid often misdiagnosed tumours (undifferentiated carcinomas, embryonal rhabdomyosarcomas, and malignant lymphomas), since carcinomas react with antikeratin, embryonal rhabdomyosarcomas with antibodies to desmin and malignant lymphomas show immunofluorescence with antibodies to vimentin. The biological behaviour (age distribution, tendency to metastasize), the normal values of biochemical parameters, homovanillic acid and vanilmandelic acid (HVA, VMA), and the absence of neurofilaments distinguish this type of tumour from the peripheral sympathetic neuroblastoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00463554
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  • 2
    Electronic Resource
    Electronic Resource
    Early stages of chemically induced liver carcinogenesis by oral administration of the antihistaminic methapyrilene hydrochloride (1983)
    Springer
    Journal of cancer research and clinical oncology 106 (1983), S. 53-57 
    Details
    ISSN: 1432-1335
    Keywords: Methapyrilene ; Liver tumor ; Preneoplasia ; Adenosine-5-triphosphatase ; γ-Glutamyltranspeptidase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The antihistaminic drug methapyrilene hydrochloride, which induces liver tumors in rats, was administrated orally to female Wistar rats. The animals were killed after 21, 38, 77, 119, 181, and 196 days. The activities of adenosine-5-triphosphatase (ATPase) and γ-glutamyltranspeptidase (γ-GT) in the liver were investigated histochemically. At 21 days, a homogeneous decrease of ATPase activity as well as a slight increase of γ-GT activity was found in the periportal zone. Additionally, after 38 days hepatocellular foci with reappearance of γ-GT occurred mainly in the periportal zone. After 119 days, foci with increased γ-GT activity as well as a significant reduction of ATPase activity could be observed predominantly in the periportal region. The size and number of these putative preneoplastic foci were increased according to the time of administration of methapyrilene hydrochloride. After 181 days of methapyrilene hydrochloride treatment three of five animals developed hyperplastic nodules with corresponding alterations of enzyme activities. Methapyrilene hydrochloride — a carcinogen with an unknown mechanism of reaction-produces preneoplastic changes that are analogous to the well known preneoplastic lesions in the liver observed after administration of other carcinogenic agents.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00399897
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Diagnostic value of intermediate filament antibodies in clinical cytology (1984)
    Springer
    Journal of molecular medicine 62 (1984), S. 114-123 
    Details
    ISSN: 1432-1440
    Keywords: Cytology ; Imprints ; Human tumors ; Cytokeratin ; Vimentin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Antibodies to intermediate filament (IF) proteins can distinguish the major tumor groups as shown by results with sectioned human material. In this study we evaluate the use of similar methods in the cytology of human tumors. Smears obtained from fine needle aspiration biopsies were investigated using well characterized antibodies, each specific for only one of the five types of intermediate filaments. Tumor cells of different carcinomas, thymomas, and the epithelial part of pulmonary blastomas were positive with antibodies recognizing cytokeratins. Tumor cells in non-muscle sarcomas, including lymphoma and Ewing's sarcoma, could be specifically identified with antibodies to vimentin. Tumor cells of muscle sarcomas were desmin-positive. Finally, tumor cells in pheochromocytoma and bronchus carcinoid were positive with antibodies specific for neurofilaments. Specimens were also examined in parallel using conventional cytochemical stains, such as May-Grünwald-Giemsa. In addition, in most cases sections of the tumor were examined both by histology and IF typing of frozen sections to confirm the diagnosis made on the cytologic specimens. The results show that IF typing is a valuable diagnostic aid in clinical cytology.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01738701
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  • 4
    Electronic Resource
    Electronic Resource
    An unusual case of adamantinoma of long bones (1982)
    Springer
    Journal of cancer research and clinical oncology 104 (1982), S. 315-320 
    Details
    ISSN: 1432-1335
    Keywords: Adamantinoma ; Pneumothorax ; Paraneoplasia ; Hypercalcemia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Adamantinoma of the tibia is a rare bone lesion, in which it is impossible to predict the biological behaviour. A case of extremely late local recurrence and lung metastasis is presented. Additionally, the patient developed pneumothorax on the right side months before intrapulmonary metastasis could be detected by X ray. Finally 1 week before her death the young woman suffered from paraneoplastic severe hypercalcemia leading to hypercalcemic coma and pancreatitis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00406250
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  • 5
    Electronic Resource
    Electronic Resource
    Typing of intermediate filaments in malignant fibrous pleural tumors (1984)
    Springer
    Journal of cancer research and clinical oncology 107 (1984), S. 43-47 
    Details
    ISSN: 1432-1335
    Keywords: Submesothelial fibrosarcoma ; Epithelial mesotheliomas ; (Cyto)keratin ; Immunocytology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We report two cases of a malignant fibrous pleural tumor, one of the localized type and one of the diffuse type. In both cases, typing of intermediate filaments by immunofluorescence microscopy showed that the tumor cells were positive for vimentin and negative for (cyto)keratin and desmin. This result supports the concept that malignant fibrous pleural tumors do not arise from the (cyto)keratin-positive pleural mesothelium but from the submesothelial fibrous tissue. Thus, instead of the usual term “malignant fibrous mesothelioma”, the term “malignant submesothelial fibrosarcoma” should be preferred.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00395489
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    Paper (German National Licenses)
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