ZIB

Hits per page

hits 1 - 2 | 2 hits

Sorting

Electronic Resource

Lack of M-MuSV tumour regression associated with T lymphocyte tolerance (1980)

Chieco-Bianchi, Luigi ; Collavo, Dino ; Zanovell, Paola ; [et al.]

[s.l.] : Nature Publishing Group

Nature 285 (1980), S. 667-668

add to mindlist on the mindlist

Details

ISSN: 1476-4687

Source: Nature Archives 1869 - 2009

Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics

Notes: [Auszug] CBA/Ca (CBA) male mice, 4 to 6 weeks old, were rendered numerically deficient in T cells by a sequence of adult thymectomy, 850 rad total-body irradiation and injection with syngeneic bone marrow cells, as detailed elsewhere5. The mice were transplanted with one thymus lobe under the kidney capsule ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/285667a0

Permalink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

Electronic Resource

Leukemia-cell rejection due to T-region encoded antigens (1981)

Biasi, Giovanni ; Collavo, Dino ; Zanovello, Paola ; [et al.]

Springer

Immunogenetics 12 (1981), S. 433-443

add to mindlist on the mindlist

Details

ISSN: 1432-1211

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Abstract The role of H-2- and T-region products in determining allogeneic cell rejection was evaluated inH-2 congenic and recombinant mice by transplanting A1ATH and A6ATL leukemia cell lines induced in A.TH and A.TL strains, respectively, by Moloney murine leukemia virus. — InK- orD-region incompatible hosts transplant failure was observed, while inI +T-region incompatible hosts either rejection or prolonged survival was seen. In mice preimmunized with spleen cells fromI- and/orT-region incompatible donors, leukemia cells were rejected by mice immune only to T-region products, and accepted by mice immune only to I-region products. — Cell-mediated cytotoxicity studies confirmed in vivo results. Secondary CTLs specifically directed against I-region products did not lyse the A1ATH and A6ATL cells, and secondary CTLs from A.TH and A.TL mice sensitized against A6ATL and A1ATH cells respectively exerted a lytic action specific for T-region products, while no activity was observed against I determinants. — The data suggest that tumor-transplant rejection may also be governed by histocompatibility antigens encoded in theT region.