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  • 1
    Electronic Resource
    Electronic Resource
    Evidence of nonlinearity in digoxin pharmacokinetics (1981)
    Springer
    Journal of pharmacokinetics and pharmacodynamics 9 (1981), S. 147-166 
    Details
    ISSN: 1573-8744
    Keywords: digoxin bioavailability ; digoxin radioimmunoassay ; plasma concentrations and urinary excretion of digoxin ; bolus injection and constant infusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Six normal male volunteers received 0.5 mg label doses of digoxin as (a) a bolus intravenous injection over 2 min, (b) a constant rate intravenous infusion over 1 hr, (c) a constant rate intravenous infusion over 3 hr, and (d) a solution in 5% dextrose given orally. Plasma concentrations of digoxin were measured by radioimmunoassay for a 4 day period and urinary excretion for a 6 day period after the single doses. The mean (coefficient of variation) total areas under the plasma concentration-time curves per 0.5 mg of digoxin were (a) 35.55 (14.8%), (b) 30.20 (27.7%), (c) 25.80 (35.5%), and (d) 15.47 (49.9%); the means differed significantly (0.01〉p〉0.005). The mean (coefficient of variation) total amounts excreted in the urine as a fraction of the dose were (a) 0.689 (6.31%), (b) 0.517 (20.4%), (c) 0.588 (16.8%), and (d) 0.374 (23.4%); the means differed significantly (p〈0.001. Both the total clearance and the nonrenal clearance of digoxin differed significantly with the method of intravenous administration. The slower the rate of input of digoxin to the body, the greater were both the total clearance and the nonrenal clearance of the drug, which strongly suggests nonlinear pharmacokinetics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01068079
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of undecanoic acid on lipid composition of Trichophyton rubrum (1983)
    Springer
    Mycopathologia 83 (1983), S. 35-39 
    Details
    ISSN: 1573-0832
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Phospholipid and neutral lipid composition of undecanoic acid (UDA) resistant mutant of Trichophyton rubrum were compared with those of the UDA sensitive parent strain of this dermatophyte. When grown in glucose-peptone broth under identical conditions, contents of neutral and phospholipids in UDA resistant mutant were nearly double of those in the UDA sensitive parent strain. Glyceride, sterol, sterol ester and phospholipid contents of mycelium increased when UDA sensitive strain was grown in presence of low concentration of UDA, sufficient to cause partial growth inhibition of this strain. UDA in growth medium did not change the lipid composition of the UDA resistant mutant.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00437411
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  • 3
    Electronic Resource
    Electronic Resource
    Condensation of azomethines with dimethyl acetylenedicarboxylate (1984)
    Springer
    Chemistry of heterocyclic compounds 20 (1984), S. 295-300 
    Details
    ISSN: 1573-8353
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The condensation of dimethyl acetylenedicarboxylate with benzylidene- and cyclohexylideneaniline, as well as with cyclohexylidene-p-toluidine and cyclohexylidene-p-anisidine, under various conditions gave 1∶1, 1∶2, and 1∶3 adducts. The structures of the isolated substances, which are formed as a result of the addition of the ester to the azomethines with subsequent 1,5-prototropic rearrangement (arylcyclohexenylvinylamines), as well as by cycloaddition (substituted dihydropyridines and spiro-cyclohexanedihydropyridines), are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00515643
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  • 4
    Electronic Resource
    Electronic Resource
    1H and 13C NMR spectra and three-dimensional structures of 1,2,5-trimethyl-4-phenylaminopiperidine isomers (1982)
    Springer
    Chemistry of heterocyclic compounds 18 (1982), S. 1174-1177 
    Details
    ISSN: 1573-8353
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The three-dimensional structures of two isomers of 1,2,5-trimethyl-4-phenylaminopiperidine were established on the basis of an analysis of their 1H and 13C NMR spectra. The piperidine ring has a chair conformation in both isomers. The δ isomer has the 1,2e,5a, trimethyl-4e-phenylaminopiperidine structure, while the γ isomer has the 1,2e,5e-trimethyl-4e-phenylaminopiperidine structure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00506367
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  • 5
    Electronic Resource
    Electronic Resource
    N-aryl-N-[1,2,5-trimethylpiperidyl-4-propamides] and their analgesic activity (1984)
    Springer
    Pharmaceutical chemistry journal 18 (1984), S. 615-618 
    Details
    ISSN: 1573-9031
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00773819
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  • 6
    Electronic Resource
    Electronic Resource
    Discrimination of a colony stimulating factor subclass by a specific receptor on a macrophage cell line (1980)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 104 (1980), S. 359-366 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Utilizing the high affinity interactions between pure 125I-L cell colony stimulating factor and its receptor(s) on the murine macrophage cell line J774, a murine radioreceptor assay (RRA) has been developed. The murine RRA selectively detects a colony stimulating factor (CSF) subclass (CSF-1) previously defined by murine radioimmunoassay (RIA) (E.R. Stanley, Proc. Nat. Acad. Sci., USA, 76:2969-2973 ('79)). CSF-1 stimulates macrophage production exclusively, and the occurrence of the CSF-1 receptor(s) appears to be restricted to cells of the mononuclear phagocytic system (L.J. Guilbert and E.R. Stanley, J. Cell Biol. 85:153-160 ('80)). The murine CSF-1 RRA failed to detect a variety of other CSF subclasses, growth factors, and hormones. In contrast to data obtained with the murine CSF-1 RIA, human CSF-1 (e.g., human urinary CSF) is detected by the mouse CSF-1 RRA almost as sensitively as murine CSF-1. In addition, there was an absolute correlation between CSF-1 levels determined by murine CSF-1 RRA and those determined by a human CSF-1 RIA for a variety of human CSF-1 sources. The murine CSF-1 RRA is a sensitive (sensitivity 5 units or 1.0 femtomole of CSF-1 protein), rapid, and highly specific assay for CSF-1 in both murine and human sources.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1041040309
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