ZIB

Hits per page

hits 1 - 2 | 2 hits

Sorting

Electronic Resource

NCI and Frederick (1983)

GILDEN, RAYMOND V. ; LIVERMAN, JAMES L. ; DAVIS, THOMAS W. ; [et al.]

[s.l.] : Nature Publishing Group

Nature 302 (1983), S. 10-10

add to mindlist on the mindlist

Details

ISSN: 1476-4687

Source: Nature Archives 1869 - 2009

Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics

Notes: [Auszug] SIR - The Nature article entitled "NCI 'mismanagement' causes unrest at Frederick" (20 January, p. 185) contains many factual errors in both dollar amounts and mode of operation and also creates the erroneous impression that the multi-contractor environment at the National Cancer ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/302010b0

Permalink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

Electronic Resource

The influence of host health and environment on natural cytotoxicity of mouse macrophages (1981)

Fidler, Isaiah J. ; Davis, Thomas W. ; Raz, Avraham

Springer

Cancer immunology immunotherapy 11 (1981), S. 195-199

add to mindlist on the mindlist

Details

ISSN: 1432-0851

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary The health and environment of the host influence the ‘natural cytotoxicity’ of mouse peritoneal macrophages against tumor targets in vitro. In these studies, we have used mice derived by hysterectomy and maintained under barrier conditions. Peritoneal macrophages harvested from untreated mice and from those that received IP injections of thioglycollate broth, bactopeptone, or soluble concanavalin A were not cytotoxic to tumor targets in vitro. Resident and various inflammatory macrophages responded alike to activation by lipopolysaccharide or macrophage-activating factor. Macrophages were rendered tumoricidal following inflammation and/or infection of the host or imposition of stressful conditions on the host. Inflammation was induced by SC injection of complete Freund's adjuvant or IP injection of Mycobacterium bovis organism into the mice. Stress was induced by crowding the mice. Macrophages obtained from mice stressed for 2 weeks by crowding were spontaneously cytotoxic to tumor targets in vitro. Moreover, macrophages obtained from mice that fought among themselves and developed skin wounds were highly tumoricidal in vitro. These data demonstrate that environmental conditions influence the activation of tumoricidal properties of macrophages in apparently healthy donors.