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  • 1
    Electronic Resource
    Electronic Resource
    Presence of alpha-adrenoceptors in human temporal arteries. Comparison between migraine patients and controls (1983)
    USA/Oxford, UK : Blackwell Science Ltd
    Cephalalgia 3 (1983), S. 0 
    Details
    ISSN: 1468-2982
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Alpha-adrenergic mechanisms have frequently been implied in migraine pathophysiology. We have examined the noradrenaline reactivity of isolated human temporal arteries removed from six migraine sufferers (not during attack) and from six patients without migraine operated for intracranial disorders. Noradrenaline constricted these vessels in a concentration-dependent manner, the response being altered by phentolamine 10−8 M to 10−6 M. There was no statistically significant difference between migraine patients and controls with respect to maximal contractile force (Emax) or pD2 (negative logarithm of the concentration eliciting half maximal force). The pA2 value for phentolamine was 8.3 in vessels from controls and 7.6 in arteries from migraine sufferers. The small difference between migraine patients and controls was not statistically significant. We obtained clear evidence of alpha-adrenergic receptors in human temporal arteries but their sensitivity was independent of the migraine disorder.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1468-2982.1983.0304219.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Substance P: Localization, concentration and release in cerebral arteries, choroid plexus and dura mater (1983)
    Springer
    Cell & tissue research 234 (1983), S. 1-7 
    Details
    ISSN: 1432-0878
    Keywords: Substance P ; Radioimmunoassay ; Cerebral arteries ; Choroid plexus ; Dura mater ; Guinea-pig ; Rabbit ; Cat ; Man
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Substance P-like immunoreactivity (SPLI) was studied by immunocytochemistry and radioimmunoassay in the cerebral arteries, choroid plexus and dura mater of the guinea-pig, rabbit, cat and man. The highest concentrations were found in cerebral blood vessels: 6.1±2.3 pmol/g (guinea-pig), 9.0±1.1 pmol/g (rabbit), 7.1±0.4 pmol/g (cat), and 2.4±0.9 pmol/g (man). Lower levels were obtained in the choroid plexus and dura mater. The distribution of substance P (SP)-immunoreactive nerve fibres found in various regions of the guinea-pig correlated well with the amount of SPLI measured. Sympathectomy did not alter the concentration of SPLI in the dura mater or in cerebral blood vessels. Electrical field stimulation or 124 mM potassium enhanced the spontaneous efflux of SPLI by 10 and 20%, respectively, from superfused pial arteries in vitro. These data are in support of a functional role of perivascular SP within the cranial circulation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00217397
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    VIP (vasoactive intestinal polypeptide)-containing nerves of intracranial arteries in mammals (1980)
    Springer
    Cell & tissue research 208 (1980), S. 135-142 
    Details
    ISSN: 1432-0878
    Keywords: Vasoactive intestinal polypeptide (VIP) ; Peptidergic nerves ; Cerebral blood vessels ; Mammals
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Immunohistochemical and radioimmunochemical investigations have shown, in various species, the occurrence of numerous nerve fibres containing vasoactive intestinal polypeptide (VIP) in connection with blood vessels of the central nervous system. Pial arteries from pig, cat, and rat have the richest supply of VIP nerve fibres; those of cow, dog, guinea pig and hamster have an intermediary number of nerves, while only few are found in pial arteries from the monkey, rabbit, gerbil, and mouse. The regional variation in VIP-nerve density follows the order: cerebral arteries 〉 cerebellar arteries 〉 basilar 〉 vertebral 〉 spinal cord arteries. Unilateral extirpation of either the pterygopalatine or the superior cervical ganglia does not affect the amount or distribution of VIP fibres in the wall of brain vessels of the ipsilateral side. Measurement of the VIP content by radioimmunoassay shows mean concentrations in the pial arteries varying between 19 and 82 pmol/g tissue wet weight. Regional and species variations in measured VIP levels are similar to the variations in distribution of immunoreactive nerve fibres.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00234179
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    Paper (German National Licenses)
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