Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Enzymes of Cerebral GABA Metabolism and Synaptosomal GABA Uptake in Acute Liver Failure in the Rabbit: Evidence for Decreased Cerebral GABA-Transaminase Activity (1984)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 42 (1984), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Measurements of the activities of the two key enzymes in cerebral GABA metabolism—glutamate decarboxylase (GAD) and GABA-transaminase (GABA-T)—were performed in normal rabbits and in rabbits with hepatic encephalopathy due to galactosamine-induced liver failure. Furthermore the uptake of GABA by synaptosomes was studied. Hepatic encephalopathy was associated with a marked decrease in the activity of GAB A-T. This decrease in activity was already apparent in galactosamine-treated rabbits before the onset of hepatic encephalopathy. Sera and serum ultrafiltrates of rabbits with hepatic encephalopathy but not of normal rabbits or of rabbits with uremic encephalopathy were shown to inhibit GABA-T activity in vitro. Cerebral GAD activity and synaptosomal GABA uptake in rabbits with hepatic encephalopathy and in untreated animals were not different. These later findings indicate that hepatic encephalopathy is not associated with alterations of presynaptic GABA nerve terminals in the central nervous system. The demonstration of a decrease in cortical GABA-T activity provides indirect evidence for decreased GABA turnover in the brains of rabbits with hepatic encephalopathy and thus is compatible with augmented GABA-ergic inhibitory neurotransmission contributing to the neural inhibition of hepatic encephalopathy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1984.tb02816.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Hemmung der Glukose und Leucin-Resorption durch Somatostatin beim Hund (1981)
    Springer
    Research in experimental medicine 178 (1981), S. 241-246 
    Details
    ISSN: 1433-8580
    Keywords: Somatostatin (growth hormone release inhibitory factor) ; Small bowel absorption ; Glucose ; Leucin ; Somatostatin ; Dünndarmresorption ; Glukose ; Leucin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In einer Resorptionsstudie an der isolierten Thiry Vella-Schlinge am wachen Hund wurde der Einfluß von Somatostatin (SST) auf die Dünndarmresorption von Glukose und Leucin untersucht. Unter SST wurde eine signifikante, aber nicht totale Hemmung der Glukoseresorption und eine prozentuell geringere signifikante Verminderung der Leucinresorption gefunden.
    Notes: Summary Small bowel absorption of glucose and leucin was investigated under the influence of somatostatin (SST) using an isolated Thiry Vella loop in the unrestrained dog. SST infusion significantly reduced glucose and leucin absorption, inhibiting glucose absorption more than that of leucin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01851013
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...