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  • 1980-1984  (2)
  • 1
    Electronic Resource
    Electronic Resource
    A Regional Study of 4-Aminobutyrate Metabolism and Amino Acid Levels in Rat Brain Following Chronic Oral Administration of Ethanolamine O-Sulphate (1982)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 38 (1982), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Ethanolamine O-sulphate (EOS) dissolved in the drinking water (5mg-ml−1) was administered ad libitum to rats for 26 days. At the end of this period, glutamate decarboxylase (GAD) and GABA-transaminase (GABA-T) activities, 4-aminobutyrate (GABA) concentration, and the levels of six other amino acids were measured in various brain regions. Significant inhibition of GABA-T accompanied by significant increases in GABA content were observed throughout the brain, although the magnitudes of these effects varied according to region. GAD activity was significantly reduced in most brain regions, although this effect was apparently not related to cofactor availability or the direct actions of EOS or increased GABA concentration. Glutamine levels were significantly reduced to approximately 72% of control values in all brain regions. Aspartate levels were significantly reduced to approximately 84% of control values in all regions except the striatum and cerebellum. Minor changes in other amino acid levels were also detected. These neurochemical changes which accompanied the primary effect of EOS on GABA-T are discussed in terms of indirect secondary metabolic changes rather than nonspecific enzyme inhibition by EOS.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1982.tb05343.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Changes in the rat sleep-wake cycle produced by DL-6-fluorotryptophan, a competitive inhibitor of tryptophan hydroxylase (1981)
    Springer
    Psychopharmacology 74 (1981), S. 369-373 
    Details
    ISSN: 1432-2072
    Keywords: DL-6-Fluorotryptophan ; Sleep wake cycle ; 5-Hydroxytryptamine ; Rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract DL-6-Fluorotryptophan (6-FT), a competitive inhibitor of tryptophan hydroxylase, produced a transient disruption of sleep in rats chronically implanted with EEG recording electrodes. In the 4 h period following the administration of 6-FT (120 mg/kg) awake time was increased, paradoxical sleep time was decreased and slow-wave sleep remained unchanged. These sleep changes were accompanied by significant reductions in brain 5-HT levels. L-Tryptophan (100 mg/kg) co-administered with 6-FT prevented the major sleep changes whereas L-leucine (100 mg/kg) was without effect. The major sleep changes produced by 6-FT were prevented by the pineal indole melatonin (20 mg/kg) but not by L-5-hydroxytryptophan (5 mg/kg). These neurochemical and drug interaction data raise the possiblity that 5-hydroxytryptamine is involved in the control of paradoxical rather than slow-wave sleep in the rat.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00432750
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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