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  • 1980-1984  (10)
Source
Material
Years
Year
  • 1
    Electronic Resource
    Electronic Resource
    Report of the 1979 meeting of the American Academy of Dermatology (1981)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental dermatology 6 (1981), S. 0 
    Details
    ISSN: 1365-2230
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2230.1981.tb02273.x
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    ULTRAVIOLET CARCINOGENESIS IN MICE AND MEN (1983)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 109 (1983), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1983.tb00551.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Langerhans cells in autosomal dominant ichthyosis vulgaris (1983)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 109 (1983), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Five patients with autosomal dominant ichthyosis vulgaris (ADI) were studied to see whether the abnormal keratinization was associated with disturbances of the appearance or the distribution of epidermal Langerhans cells (LCs). The LCs were identified by ATPase staining and electron microscopy. They were present in normal numbers, were of normal morphology and were in their usual mid-epidermal position. These observations do not support the hypothesis that LCs are involved directly in the process of keratinization.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1983.tb03546.x
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    How does PUVA inhibit delayed cutaneous hypersensitivity? (1982)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 107 (1982), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The inhibitory effect of PUVA on delayed cutaneous hypersensitivity to 2,4-dinitrochloroben-zene (DNCB) has been analysed by sensitizing and challenging patients with psoriasis on shielded and treated areas of skin, and comparing the results with those for untreated patients. PUVA suppresses both induction and expression of delayed cutaneous hypersensitivity by systemic as well as local actions, but the major effect is local inhibition of induction. The possible contributions of Langerhans cell depletion, impaired lymphocyte reactivity, and reduced cutaneous inflammatory responses are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1982.tb00400.x
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Impaired contact hypersensitivity in untreated psoriasis and the effects of photochemotherapy and dithranol/UV-B (1981)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 105 (1981), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Cell mediated immune reactivity was studied in eighty-five psoriasis patients and twenty-five healthy controls by an improved (quantitative) method for measuring contact hypersensitivity to 2,4 dinitrochlorobenzene (DNCB). Patients were sensitized with 500 μg DNCB, the lowest dose found to sensitize all healthy subjects. Responses to epicutaneous challenge with a series of concentrations of DNCB were measured as volumes calculated from diameter and thickness and the various groups were compared by the differences in the log dose-response curves. Patients with untreated psoriasis were less responsive than healthy controls; responses were less still in patients treated with dithranol/UV-B/tar and they were least of all in patients treated with photochemotherapy with 8-methoxypsoralen and UV-A (PUVA), particularly in those who pigmented least. Sensitization and challenge at different stages of treatment showed that both induction and elicitation of sensitization were impaired by PUVA. The possible relationship of these changes to DNCB metabolism, Langerhans cell damage and a decrease in circulating T cells is discussed. Although the clinical significance of the findings is unknown, treatment with dithranol/UV-B/tar has proved safe over many years of use.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1981.tb00792.x
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Reappearance of epidermal Langerhans cells after PUVA therapy (1983)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 109 (1983), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Epidermal Langerhans cells (LC) disappear during photochemotherapy (PUVA) with 8-meth-oxypsoralen (8-MOP) and long wavelength ultraviolet (UV-A) radiation. The time course of their disappearance during treatment and their reappearance after its completion was followed. Langerhans cells lost ATPase activity before they disappeared by ultrastructural criteria: thus 90% of ATPase-stained cells had disappeared after seven treatments (2 weeks) whereas it was only after fifteen treatments (5 weeks) that they were seen to be reduced on electron microscopy. Their numbers remained low throughout the course of treatment but they had returned to normal by 3 weeks after cessation of therapy.Since PUVA lamps also emit traces of medium wavelength UV (UV-B) the separate effects of UV-A and UV-B in the presence and absence of 8-MOP were examined. Within the dose range normally used for therapy, the LC disappeared only with the combination of UV-A and 8-MOP.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1983.tb03545.x
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Decreased lymphocyte reactivity and auto-immunity in alopecia areata (1981)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 105 (1981), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: T lymphocyte numbers and functions were measured in forty-six patients with alopecia areata and thirty healthy controls. In patients with alopecia areata, lymphocyte reactivity to extracts of scalp and hair follicles was not detected by 3H thymidine incorporation. 3H Thymidine incorporation by lymphocytes cultured with PPD, Varidasc and C. albicans was significantly reduced in cells from patients compared with controls and correlated with the extent of hair loss and the presence of antithyroid antibodies. Decreased lymphocyte responses to PPD and Varidase were not due to the presence of suppressor monocytes because removal of monocytes with carbonyl iron did not increase lymphocyte reactivity. However, responsiveness to C albicans was augmented by removal of monocytes.T cell numbers were significantly lower than in controls (P〈0.005); patients with auto-antibodies had fewer T cells than patients without them.The relationship of reduced T cell function and auto-immunity to alopecia areata is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1981.tb01199.x
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    Paper (German National Licenses)
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  • 8
    Electronic Resource
    Electronic Resource
    Response of alopecia areata to DNCB: influence of auto–antibodies and route of sensitization (1981)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 105 (1981), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The effects of treatment with topical 2,4–dinitrochlorobenzene (DNCB) were observed in fifty–one patients with alopecia areata of at least 9 months duration. Patients were sensitized either by the application of 500 μg of DNCB in acetone to the forearm, or by painting affected areas of the left side of the scalp with a 1 % solution. A mild to moderate dermatitis was maintained by weekly applications of DNCB.When the sensitizing dose was applied directly to the scalp, significantly more patients showed poor reactivity as judged by the eczematous response obtained, although the two routes of sensitization had comparable effects upon regrowth of hair.Hair regrew significantly more frequently in females. The likelihood of regrowth was reduced in patients with hair loss of long duration and in those with immunological disturbances such as autoantibodies or low T lymphocyte numbers and responses. The relationship of these factors to the disease and to the response to DNCB treatment is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1981.tb01287.x
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    Paper (German National Licenses)
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  • 9
    Electronic Resource
    Electronic Resource
    Alopecia areata and auto-immunity (1981)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 105 (1981), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The prevalence of auto-antibodies against thyroid constituents, gastric parietal cells, smooth muscle cells, mitochondria, reticulin, nuclear constituents and rheumatoid factor in 108 patients with alopecia areata was compared with that found in a previous survey of the local population. Female patients had a significantly increased prevalence of anti-thyroid antibodies which were present in 30% overall and in 44% of the youngest age group (11–17 years). Smooth muscle antibodies were more frequent in female patients but the increase was not significant. Male patients had a significantly increased prevalence of thyroid and gastric parietal cell antibodies (11.4% each). In females, antithyroid antibodies were associated with extensive hair loss: they were found in 42% of female patients with total alopecia and only 20% of males with total hair loss.A family history of alopecia areata was obtained from 24% of patients; 10% had relatives with thyroid disease and 10% had diabetic relatives. These findings confirm the association between alopecia areata and the other auto-immune diseases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1981.tb01200.x
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    Paper (German National Licenses)
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  • 10
    Electronic Resource
    Electronic Resource
    Disappearance of epidermal Langerhans cells during PUVA therapy (1981)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 105 (1981), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The numbers and morphological appearance of epidermal Langerhans cells (LCs) were studied in twenty-five patients with psoriasis receiving treatment with 8-methoxypsoralen (8-MOP) and long wavelength UV irradiation (UV-A) (PUVA). After a single exposure, LCs showed loss of fine dendritic processes. Repeated treatments resulted in a reduction of the number of LCs from the mean pretreatment value of 713/mm2 to less than 60/mm2 after seven treatments. The number of LCs remained low while treatment continued for up to 4 weeks. This finding may explain the impaired contact hypersensitivity observed in patients with psoriasis receiving PUVA therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1981.tb01209.x
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    Paper (German National Licenses)
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