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  • 1980-1984  (4)
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Material
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Year
  • 1
    Electronic Resource
    Electronic Resource
    Chemotherapy for the carcinoid syndrome (1981)
    Springer
    Cancer chemotherapy and pharmacology 5 (1981), S. 133-138 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Patients with carcinoid syndrome usually die from carcinomatosis, rather than the pharmacological effects of the tumour. Functioning carcinoid tumours are resistant to radiotherapy. Twenty-four different cytotoxic drugs or combinations have been used to treat the carcinoid syndrome, but only actinomycin D, cyclophosphamide, 5-fluorouracil, melphalan, methotrexate, and streptozotocin have been tried as single agents in more than five patients. 5-Fluorouracil and streptozotocin were the most effective single agents, but their use in combination did not increase response rates. No drug combination was superior to single-agent therapy. Adriamycin has not been tested as a single agent, but results with it used in combination suggest it should be further evaluated. Liposome-encapsulated drugs may be tested, because of selective hepatic uptake.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00258469
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Cytosine arabinoside triphosphate production in human leukaemic myeloblasts: Interactions with deoxycytidine (1981)
    Springer
    Cancer chemotherapy and pharmacology 5 (1981), S. 185-192 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effect of 1 μM deoxycytidine (dC) on Ara-C conversion to Ara-CTP and on inhibition of DNA synthesis by Ara-C was measured in intact leukaemic myeloblasts. dC decreased Ara-CTP production in blasts with high Ara-C phosphorylation, but not those with low activity. The Ki for dC was similar to values found with partially purified deoxycytidine kinase. The change in Ara-CTP concentration was associated with a proportional reduction in inhibition of DNA synthesis. dC decreased the effects of Ara-C by inhibition of Ara-CTP production, rather than by production of dCTP and competition with Ara-CTP. Since low Ara-CTP production in patients' blasts is a predictor of poor therapeutic response to Ara-C, the use of dC with Ara-C may improve the therapeutic index in this group of patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00258478
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Tryptophan in the treatment of carcinoid crisis (1983)
    Springer
    Cancer chemotherapy and pharmacology 10 (1983), S. 137-139 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A 56-year-old woman was admitted with carcinoid crisis and became comatose. Blood tryptophan at this stage was 5 μg/ml; after treatment with 3.4 g tryptophan daily her level of consciousness improved and blood tryptophan increased to 10 μg/ml. The carcinoid syndrome was not exacerbated by tryptophan. Tryptophan may have a supportive role in the management of carcinoid crisis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00446228
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    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    The relationship of Ara-C metabolism in vitro to therapeutic response in acute myeloid leukaemia (1982)
    Springer
    Cancer chemotherapy and pharmacology 9 (1982), S. 30-35 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Ara-C phosphorylation and Ara-C deamination was measured in vitro, using intact marrow myeloblasts from 25 patients with previously untreated acute myeloid leukaemia. At Ara-C concentrations above 10 μM there was no longer a linear relationship of phosphorylation to Ara-C concentration. Ara-U production was measured by sampling the incubation medium. This method showed greater Ara-U production than previous methods sampling the cell pellet alone. However, Ara-CTP/Ara-U ratios from intact myeloblasts were much higher than those recorded in studies using lysed myeloblasts. Using 1 μM Ara-C, a concentration representative of in vivo concentrations, deamination and phosphorylation were related to therapeutic response to Ara-C-containing drug regimens. There was no significant correlation of these variables with response, although 5/16 non-responders had low Ara-C phosphorylation (〈1.5 pmol/106 cells/45 min/l pm Ara-C) compared with 0/9 responders. Measuring deaminase activity did not help in selecting non-responders. Even in patients with low phosphorylation increasing Ara-C concentration increased Ara-CTP levels proportionally, but up to 10 times conventional doses may be necessary to exceed endogenous dCTP levels.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00296758
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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