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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of medicinal chemistry 26 (1983), S. 1784-1785 
    ISSN: 1520-4804
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 103 (1981), S. 2340-2347 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-1076
    Keywords: Complement, neonatal concentrations and activation ; Susceptibility to infection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Determinations of C3, C4, and C5 concentrations by radial immunodiffusion, and assays for the activation products of C3, C3c and C3d by counter-immunoelectrophoresis, were performed on 80 infants. Seven nonbacteremic preterm infants with necrotizing enterocolitis (NEC) or probable NEC (PNEC) were found at the time of diagnosis to have a significantly lower mean concentration of C3 (P〈0.05, 1-tailed) without C3 activation when compared to other noninfected preterm infants. Ten full-term and 63 preterm infants were studied prospectively during the first days of life, and were then followed for the postnatal development of localized or systemic infection. Assays for the detection of C3 activation products were negative in all these infants. Four preterm infants who developed PNEC after 5 or more days without clinical illness had low original concentrations of complement components. The pathogenesis of NEC may not involve primarily complement activation, and susceptibility to this condition may be related to pre-existing deficiencies in complement component concentrations relative to gestational age, or to defective activation of C3 in the presence of certain bacterial species and strains.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wurde eine Vergleichsuntersuchung eines Al (OH)3 adsorbierten polyvalenten Spaltimpfstoffes mit einem entsprechenden Fluid-Impfstoff bei jungen Erwachsenen im Jahre 1979 durchgeführt. Im Abstand von 28 Tagen wurden zwei Injektionen verabreicht. Die Nebenwirkungen wurden über Fragebogen erfaßt, die Antikörperantwort im Hämagglutinationstest (HI) und bei einem Teil der Impflinge im Neuraminidase-Hemmungstest (NI) bestimmt. Die Nebenwirkungen waren allgemein gering, jedoch signifikant häufiger in der Adsorbatimpfstoffgruppe. Etwa 90% der Impflinger hatten vor der Impfung HI-Titer 〈 32 gegen den im Impfstoff enthaltenen A/Brazil/11/78 (H1N1). Über 50% der nach 1955 geborenen Impflinge mit so niedrigen Antikörpertitern zeigten eine sekundäre Immunantwort. Der NI erwies sich als wesentlich empfindicherer Test für die Erfassung einer Grundimmunität. Die Antikörperantwort der Impflinge mit Grundimmunität war gleich gut für beide Impfstofftypen. Für Personen ohne Grundimmunität waren zwei Injektionen notwendig, um bei etwa 80% der Impflinge Titer von ≥ 32 zu erhalten. Wieder ließ sich kein Unterschied zwischen den beiden Impfstofftypen feststellen. Aufgrund der Ergebnisse dieser und anderer Studien besteht kein Grund, Aluminiumhydroxid-adsorbierte Influenzavakzinen zu verwenden.
    Notes: Summary A comparative clinical trial with an aluminium hydroxide absorbed polyvalent tween-ether split influenza vaccine and a tween-ether split fluid vaccine of equal antigenic content was performed in young adults in 1979. Two vaccinations were given 28 days apart. Reactogenicity was evaluated by means of a questionnaire and the antibody response by the hemagglutination inhibition test (HI). The anti-Nl-neuraminidase response (NI) was determined in some of those who were vaccinated. Although reactogenicity was low, there were significantly more local reactions reported from those receiving Al (OH)3 adsorbed vaccines. Prior to vaccination approximately 90% of the volunteers' antibody titers to A/Brazil/11/78, the H1N1 strain contained in the vaccine, were 〈32. More than 50% of the volunteers with low titered antibody born after 1955 responded with a booster reaction to H1N1. Neuraminidase-inhibition tests proved to be a much more sensitive indicator of priming. The antibody response in the primed individuals was highly satisfactory after one vaccination and there was no difference between the two vaccine types. In non-primed subjects two injections were necessary to reach a titer of ≥ 32 in approximately 80% of the volunteers for A/Brazil/11/78. There was no difference in the response to the two types of vaccine. The results of these and other studies show that it is not warranted to use aluminum adsorbed influenza vaccines.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 19 (1983), S. 1871-1880 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: The heating (or cooling) of the rock adjacent to water flowing through a crevice is of interest in certain geothermal studies. For many purposes, only the rock temperature at the rock-water interface is needed. The fact that the convective heat transfer coefficient is a function of time in the case of unsteady flow takes this problem out of the strictly classical domain.Several methods of solution are described. An approach in which the heat equation is solved, under appropriate side conditions, by standard finite difference techniques is shown to be satisfactory but rather wasteful because much unneeded information concerning internal rock temperatures must be obtained. Several integral equations of Volterra type are derived that provide the temperature only at the interface. Two numerical approaches to their solution are described: one quite classical and only partially effective; the other an apparently new algorithm that is fast and efficient. Analytical upper and lower bounds on the temperature are obtained and serve to demonstrate that this numerical device is also very accurate.The algorithm is applicable to a wide class of Volterra integral equations of the second kind. A brief discussion of the possible future uses of this scheme and the need for additional research is given.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
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