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  • 1980-1984  (2)
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  • 1
    Electronic Resource
    Electronic Resource
    Analysis of the HLA-DRw8 haplotype: Recognition by HTC typing of three distinct antigen complexes in Caucasians, Native Americans, and Orientals (1983)
    Springer
    Immunogenetics 17 (1983), S. 399-410 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract We have used seven HLA-D homozygous typing cells (HTC) in a comparative study of the DRw8 antigen complex in three racial groups. Three distinct HLA-D specificities were recognized, each associated with HLA-DRw8. Four of the HTC defined a DRw8-associated HLA-D specificity designated 8.1, one defined a specificity designated 8.2, and two defined a specificity designated 8.3. Each of the three spec cities showed an association with a distinct racial group: Dw“8.1” in Caucasians, Dw“8.2” in Pacific Northwest Indians, and Dw“8.3” in Orientals. An informative primed lymphocyte (PLT) cell generated against a Dw“8.1” haplotype was able to distinguish 8.1 from 8.2 and 8.3. Using selected anti-DRw8 sera, a serologic distinction between 8.1 and 8.3 could also be made. It was thus possible, by using both cellular and serologic techniques in a comparative population study, to recognize at least three HLA-D-defined splits of the DRw8 haplotype.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00372458
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Differential behavior of cytotoxic effector cells against HLA antigens in strong genetic linkage disequilibrium (1981)
    Springer
    Immunogenetics 13 (1981), S. 297-309 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Five sets of cytotoxic effector cells were generated, using haploidentical, first degree relatives in five different families, against the HLA-A3; B7 serological determinants combined with different DR antigens. When tested against a panel of cells bearing combinations of the HLA-A, -B and -DR antigens it was shown that the HLA-B7 antigen was as strong a CML target determinant alone as it was in the presence of HLA-A3. The strength of the HLA-A3 antigen as target determinant varied. With effector cells primed to the HLA-A3; B7; DR2 haplotype, the A3 antigen alone behaved as a weak target determinant. When the same target cells were tested with the effector cells generated against HLA-A3; B7 without DR2, the A3 antigen behaved as a strong target determinant. A number of target cells lacking the serologically detectable HLA determinants present on the sensitizing HLA haplotype were identified as being killed by specific effector cells. These data suggest either a number of new CML target determinants controlled by different loci or the presence of a single, new locus with multiple alleles controlling CML targets.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00364495
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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