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  • 1
    Electronic Resource
    Electronic Resource
    Influence of prostaglandin-synthesis inhibitors on carbachol-and histamine-induced vasodilatation in perfused rat hindquarters (1983)
    Springer
    Pflügers Archiv 397 (1983), S. 290-294 
    Details
    ISSN: 1432-2013
    Keywords: Histamine ; Carbachol ; Prostaglandin inhibitors ; Vasodilation, histamine ; Vasodilatation, carbachol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: abstract In perfused rat hindquarters, in which vascular tone was maintained by norepinephrine, carbachol-induced dilatations were blocked by atropine (10−7 M), while histamine dilatations were inhibited as well by mepyramine (10−6 M) as by cimetidine (10−5 M) indicating a histamine effect through both H1- and H2-receptors. This double-receptor histamine effect was confirmed by the observation that speccific H1- and H2-receptor agonists, respectively PEA (2-pyridyl-ethylaminedihydrochloride) and dimaprit also produced a vasodilation. Carbachol- and histamine-induced dilatations were also inhibited by ETYA (5,8, 11,14-eicosatetraynoic acid) and quinacrine but not by indomethacin. The inhibition of the histamine vasodilatation appeared to rest on an interference with the H1-receptor mechanism. It is concluded that metabolites of arachidonic acid possibly mediate the dilating effect of carbachol, acting through muscarine receptors, and of histamine, acting through H1-receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00580263
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Correction of CSF HCO 3 − after its experimental increase in normocapnia (1982)
    Springer
    Pflügers Archiv 393 (1982), S. 157-163 
    Details
    ISSN: 1432-2013
    Keywords: Cerebrospinal fluid ; Blood-brain barrier ; Acidosis ; Alkalosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In anesthetized normocapnic dogs CSF [HCO 3 − ] was increased to 33 mmol/l by perfusing the brain ventricles for 45 min with a mock CSF containing a high [HCO 3 − ]. In dogs with normal plasma [HCO 3 − ], CSF [HCO 3 − ] fell by ca. 7 mmol/l in 2 h following the end of the perfusion. Lowering plasma [HCO 3 − ] to 11 mmol/l by infusing HCl intravenously was without effect but increasing plasma [HCO 3 − ] to 36 mmol/l by infusing Na2CO3 limited the CSF [HCO 3 − ] fall to 2.8 mmol/l. It is concluded that correction of CSF [HCO 3 − ] is partially dependent on a sufficiently low plasma [HCO 3 − ]. The small and persistent fall of CSF [HCO 3 − ] which at high plasma [HCO 3 − ] occurs against a concentration gradient with blood suggests moreover the contribution of more specific mechanism(s) for lowering CSF [HCO 3 − ] after its experimental increase.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00582939
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    pH aspects of transient changes in conduction velocity in isolated heart fibers after partial replacement of chloride with organic anions (1981)
    Springer
    Pflügers Archiv 389 (1981), S. 199-209 
    Details
    ISSN: 1432-2013
    Keywords: Organic anions ; Conduction velocity ; Metabolic acidosis ; Intracellular pH ; Heart fibers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Conduction velocity in isolated rabbit atrial fibers was continuously measured in solutions having a different anionic composition. When 20 mmol/l of chloride was replaced by 20 mmol/l lactate or other anions of weak organic acids at constant pH 6.8, biphasic initial transient changes in conduction velocity were observed. The produced transient changes had a greater amplitude with organic acids which have a greater pK and lipid/water partition ratio. The magnitude of the transients was also greater at pH 6.8 than at pH 7.5, and also when the buffering capacity of the superfusion solution was smaller. Measurements of intracellular pH (pHi) in sheep Purkinje fibers and of pH at the surface (pHs) of sheep Purkinje and rabbit atrial fibers with pH sensitive microelectrodes, showed a transient increase of pHs and a sustained decrease of pHi on replacement of 20 mmol/l chloride by organic anions of weak acids (at constant pH of the superfusion solution). A combined influence of the transient pHs change and the sustained pHi modification seems to be important in the explanation of the biphasic changes in conduction velocity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00584780
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Correction of CSF HCO 3 − after its experimental increase in normocapnia: Inhibition by acetazolamide (1983)
    Springer
    Pflügers Archiv 396 (1983), S. 66-71 
    Details
    ISSN: 1432-2013
    Keywords: Cerebrospinal fluid ; Blood brain barrier ; Carbonic anhydrase inhibition ; Acidosis ; Alkalosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In anaesthetized normocapnic dogs CSF [HCO 3 − ] was increased to ca 33 mmol/l by perfusing the brain ventricles for 45 min with a mock CSF containing a high [HCO 3 − ] which in addition contained 2.5 mg/ml acetazolamide to inhibit central carbonic anhydrase. In dogs with normal plasma [HCO 3 − ], CSF [HCO 3 − ] fell by 5.4 mmol/l in 2 h following the end of the perfusion. Lowering plasma [HCO 3 − ] to 11 mmol/l by infusing HCl intravenously increased the CSF [HCO 3 − ] fall to 7.5 mmol/l. Increasing plasma [HCO 3 − ] to 36 mmol/l completely impeded the fall in CSF [HCO 3 − ]. It is concluded that in these experiments clearing of HCO 3 − from the CSF is critically dependent on plasma [HCO 3 − ]. When the data are compared to those of comparable experiments without intraventricular administration of acetazolamide (Weyne et al. 1982), they indicate that acetazolamide impedes clearing of HCO 3 − from CSF at high and at normal plasma [HCO 3 − ] but not at low plasma [HCO 3 − ]. The experiments therefore suggest a dual contribution for the clearing of HCO 3 − from the CSF after its experimental increase: diffusion along the CSF-plasma gradient for HCO 3 − and a carbonic anhydrase dependent clearing of HCO 3 − .
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00584700
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    Paper (German National Licenses)
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