ISSN:
1432-0738
Keywords:
Methylmercury
;
Selenium
;
Peripheral nerve
;
Neurotoxicity
;
Rat
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract In order to see chronological relationship between electrophysiological changes and “early” neurological sign (tail rotation) elicited in rats poisoned with methylmercury, we made serial measurements of amplitude of compound action potential and sensory nerve conduction velocity of the tail nerve in rats with five dose schedules [methylmercury vs selenium, (1)20 ppm : 0.1 ppm, (2)20 ∶ 0.3, (3)20 ∶ 0.6, (4)10 ∶ 0.1, (5)10 ∶ 0.6]. We observed the following sequence in the onset of neuro-electrophysiolo-somatic signs: fall in compound action potential 〉 decrease in sensory nerve conduction velocity 〉 tail rotation 〉 weight loss. Protective potency of dietary selenium against neurotoxicity of methylmercury was observed with regard to both electrophysiological changes and neurological signs.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00333897
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