ISSN:
1432-2072
Keywords:
Aggression
;
Attack
;
Agonistic behavior
;
Locomotion
;
Stereotyped behavior
;
d-Amphetamine
;
Cocaine
;
Tolerance
;
Sensitization
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Agonistic, locomotor, and stereotyped behavior were measured in male Swiss-Webster mice in their home cage, normally shared with a female, while confronting an intruder mouse. Acute administration of d-amphetamine (2, 4, 8 mg/kg, IP) to resident mice decreased the frequency of attacks toward an untreated intruder, increased the resident's locomotor activity, and induced a small amount of stereotyped behavior. Redetermination of dose-effect functions during chronic treatment (8 or 16 mg/kg/day) indicated that tolerance did not develop to the antiaggressive effect of d-amphetamine. By contrast, the chronically treated mice showed sensitization to amphetamine-induced stereotypies and a diminished sensitivity to the drug's enhancement of locomotor activity. Subsequent tests with cocaine indicated no differences between amphetamine-maintained and saline control animals, providing no evidence for cross-tolerance or cross-sensitization between cocaine's and amphetamine's effects on attack, locomotion, and stereotypies.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00432140
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