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  • 1980-1984  (3)
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Material
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Year
  • 1
    Electronic Resource
    Electronic Resource
    Use of HLA loss mutants to analyse the structure of the human major histocompatibility complex (1982)
    [s.l.] : Nature Publishing Group
    Nature 296 (1982), S. 454-456 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] pHLA-1 (Fig. Ib, c) contains a 513-base pair (bp) cDNA insert which corresponds to the COOH-terminal 46 amino acids of an HLA class I heavy chain plus a portion of the 3'-noncoding region of the mRNA3. To make a preliminary estimate of HLA class I gene family size, genomic DNA was isolated from a ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/296454a0
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Class I-like HLA genes map telomeric to the HLA-A2 locus in human cells (1983)
    [s.l.] : Nature Publishing Group
    Nature 302 (1983), S. 534-536 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] We studied DNA from human lymphoblastoid cell line LCL 721 and mutants of it, 721.45.1 and 721.127 (unpublished), from which one entire haplotype or the other had been physically deleted by ?-irradiation. Most important, however, was the analysis of the mutant 721.144 having an A phenotype that ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/302534a0
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Mapping of class I DNA sequences within the human major histocompatibility complex (1983)
    Springer
    Immunogenetics 18 (1983), S. 489-502 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Mutants that had lost expression of alleles of one or more HLA loci were isolated with immunoselection after γ-irradiation of a human lymphoblastoid cell line LCL 721. DNAs from the mutants were digested with restriction endonucleases and analyzed by Southern blotting using probes for class I HLA genes. Eight polymorphic cut sites for HindIII and PvuII were discovered in class I-associated sequences of LCL 721. Losses of specific fragments generated by restriction enzymes could be associated with losses of specific antigenic expressions and it was possible in this way to assign HLA-Al, HLA-A2, and HLA-B8 to specific DNA fragments. Patterns of γ-ray-induced segregations of DNA fragments permitted rough linkage alignment of about 30% of the fragments generated by PvuII. The resultant map showed that there are class I HLA genes on the telomeric side of the HLA-A locus. Restriction enzyme site polymorphisms were also examined in a panel of DNAs isolated from peripheral blood lymphocytes (PBLs) of HLA-typed individuals. This panel of PBL DNA complemented the analysis using the HLA deletion mutants.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00364390
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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