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  • 1980-1984  (2)
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Material
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  • 1
    Electronic Resource
    Electronic Resource
    The transmembrane gradient of osmotic pressure modifies the kinetics of sodium currents in perfused neurons (1983)
    Springer
    Cellular and molecular life sciences 39 (1983), S. 494-495 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Sodium TTX-sensitive current was investigated in isolated, internally perfused neurons of rat spinal ganglia. The transmembrane osmotic pressure gradient was found to slow the kinetics of sodium current inactivation when the external osmolality was increased and to speed up the kinetics when the external osmolality was decreased.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01965171
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Action of neurotoxin from the sea anemoneHomostichanthus duerdemi on inward sodium current in mammalian neurons (1982)
    Springer
    Neurophysiology 14 (1982), S. 303-309 
    Details
    ISSN: 1573-9007
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The action of purified toxin from the sea anemoneHomostichanthus duerdemi (HTX-1) on the inward sodium current was studied in experiments on isolated neurons from rat spinal ganglia and neuroblastoma cells of clone N-18F1, by an intracellular perfusion and voltage clamp method. HTX-1 was found to delay inactivation of the tetrodotoxin-(TTX-)sensitive inward sodium current and to make it incomplete, but virtually without affecting its activation. The relationship between the fraction of sodium channels modified by the toxin and the HTX-1 concentration is described by a Langmuir isotherm with association constant of (1.1 ± 0.1)·10−7 M (holding potential −100 mV). Under the influence of the toxin the peak inward sodium current was increased by about 80%. Binding of HTX-1 with TTX-sensitive sodium channels is distinguished by strong potential-dependence: at a holding membrane potential of 0 mV the binding constant was an order of magnitude less than at a potential of −100 mV. In the case of brief action of HTX-1 on the nerve cell membrane (under 5 min) the effect of the toxin was completely reversible, but if the time of action of HTX-1 exceeded 30 min, subsequent washing with normal solution for 90 min did not abolish the effect completely.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01058740
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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